Terlipressin Acetate oo loogu talagalay Dhiigbaxa Kala-duwanaanshaha Esophageal
Faahfaahinta Alaabta
| Magaca | N-(N- (N-Glycylglycyl) glycyl) -8-L-lysinevasopressin |
| Lambarka CAS | 14636-12-5 |
| qaacidada molecular | C52H74N16O15S2 |
| Miisaanka molecular | 1227.37 |
| Lambarka EINECS | 238-680-8 |
| Barta karkarinta | 1824.0± 65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.46±0.1 g/cm3 (La saadaaliyay) |
| Xaaladaha kaydinta | Ku hay meel mugdi ah, jawi aan fiicneyn, ku kaydi qaboojiyaha, ka hooseeya -15 ° C. |
| Isku-dhafka aysiidhka | (pKa) 9.90±0.15 (La saadaaliyay) |
La mid ah
[N-α-Triglycyl-8-lysine] -vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine] -vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, terlipressin, terlipressin, terlipressin.
Sharaxaada
Terlipressin, oo magaciisa kiimikaad yahay triglycyllysine vasopressin, waa diyaarinta vasopressin cusub oo muddo dheer shaqaynaysa.Waa nooc ka mid ah dawooyinka, kaas oo aan firfircoonayn laftiisa.Waxaa ku dhaqma aminopeptidase in vivo si tartiib tartiib ah "sii daayo" lysine vasopressin firfircoon ka dib markii ay ka saareen saddexda glycyl hadhaagii N-terminus.Sidaa darteed, terlipressin waxay u shaqeysaa sidii kayd kayd ah oo sii daaya lysine vasopressin si joogto ah.
Saamaynta dawooyinka ee terlipressin waa in la isku xidho muruqa siman ee xididdada xididdada dhiigga iyo in la yareeyo socodka dhiigga splanchnic (sida yaraynta socodka dhiigga ee mesentery, beeryarada, ilmo-galeenka, iwm.), taas oo yaraynaysa socodka dhiigga portal iyo cadaadiska portal.Dhanka kale, waxay sidoo kale hoos u dhigi kartaa balasmaha Saamaynta feejignaanta renin, taas oo kordhinaysa socodka dhiigga kelyaha, hagaajinta shaqada kelyaha iyo kordhinta wax soo saarka kaadida ee bukaanka qaba hepatorenal syndrome.Terlipressin hadda waa daawada kaliya ee hagaajin karta heerka badbaadada bukaanada qaba dhiigbaxa hunguriga.Waxaa inta badan loo isticmaali jiray daawaynta kiliinikada ee dhiigbaxa variceal.Intaa waxaa dheer, terlipressin ayaa sidoo kale si guul leh loogu isticmaalay beerka iyo kelyaha.Guud ahaan, waxay u badan tahay inay door faa'iido leh ka ciyaarto wada noolaanshaha shoogga refractory iyo dib u soo kicinta wadnaha sambabada.Marka la barbardhigo vasopressin, waxay leedahay saameyn dheer oo joogto ah, ma keento dhibaatooyin halis ah, oo ay ku jiraan fibrinolysis iyo dhibaatooyinka halista ah ee habka wadnaha iyo xididada, waana sahlan tahay in la isticmaalo (mudidda xididka), taas oo ku habboon daryeelka degdega ah iyo khatarta ah.Badbaadinta iyo daawaynta bukaanada aadka u xanuunsan.
