Terlipressin waxay u asaasay dhiig baxa dhiig-baxa
Si faahfaafo
| Magac | N- (n- (n-glycylglycyl) glycyl) -8-L-Lyysinevasosopressin |
| Lambarka CAS | 14636-12-5-5 |
| Qaaciddada molika | C52h74n16o15s2 |
| Miisaanka Moleculal | 1227.37 |
| Tirada EINECS | 238-680-8 |
| Point karkaraya | 1824.0 ± 65.0 ° C (saadaaliyay) |
| Cucid | 1.46 ± 0.1 g / cm3 (saadaaliyay) |
| Xaaladaha kaydinta | Ku hay meesha mugdiga ah, jawiga firfircoon, ku keydi qaboojiyaha, ka yar -15 ° C. |
| Isutirka aashitada | (PKA) 9.90 ± 0.15 (la saadaaliyay) |
Ereyo isku mid ah
[N-α-triglycyl-8-LYSEINE] -Lessissopressic-ka; 130: PN: WO2010033333333Claide: 1-triglycyl-8-Lyynevasopoprentan; Nα-glycyl-glycyl-glycyl-glycyl- [8-LYSENE] -VAPOPINEN; Nα-glycyl-glycyl-glycyl-lveline-vasepoprentan; Nα-glycylglglycylgllycyl-vasoprentan; Nα-gly-gly-gly-gly-yeeyprentan; Terlipresidin, Terlipresine, Terliposina, Terlipresinaanta.
Sifo
Terlipresisin, oo magacooda kiimikaad ah ay tahay Triglycyllysine vaopopressin, waa diyaarinta cusub ee Vopression-ka oo cusub. Waa nooc ka mid ah proprug, oo iskeed u shaqeynaya. Waxaa ku dhaqma iyada oo loo yaqaan 'aminopoptiduc' ee vivo si tartiib tartiib ah "siidaynta" Lysine Vopopressirka Firfircoon ee Lysine Vanopressirka ka dib markii uu ka saarayo saddexda haraaga Glycyl ee N-Eernas. Sidaa darteed, Terliperesisin wuxuu u dhaqmayaa sidii kayd ah oo ah kayd ah oo ku sii daraya Lysine vasopressing si joogto ah.
Saamaynta dawooyinka dawooyinka ee terlipresiska ayaa ah qandaraas-qaddarta muruqyada xididdada xididdada (sida yareynta qulqulka dhiigga (ufahuhu, ilmo galeenka, iwm.),, Iwm. Dhanka kale, waxay sidoo kale yareyn kartaa plasma saameynta plasma ee ka fiirsashada RENIN, taas oo kordhaysa socodka qulqulka dhiiga, hagaajinta shaqada kalyaha iyo kordhinta wax soo saarka kaadida ee bukaannada leh hepatonal syndrome. Terlipressing hadda waa dawada kaliya ee hagaajin kara heerka badbaadada ee bukaannada qaba dhiig baxa dhiig baxa. Waxaa inta badan loo adeegsaday daaweynta caafimaad ee dhiigbaxa varisial-ka. Intaa waxaa sii dheer, Terlipresisin ayaa sidoo kale si guul leh loogu adeegsaday beerka iyo kelyaha. Guud ahaan, waxay u badan tahay inay door faaqitaan ah ka ciyaarto shoog dib-u-dhac ku saabsan naxdinta leh iyo dib u soo kicinta wadnaha ee wadnaha. Marka la barbar dhigo Vanopressin, waxay leedahay saameyn muddo-dheer, oo aan u keenin dhibaatooyin khatar ah, oo ay ku jiraan fibrinolysis iyo dhibaatooyin daran oo ku saabsan nidaamka wadnaha, waana sahlan tahay in la isticmaalo (kaas oo ku habboon in lagu hayo daryeelka degdegga ah iyo kan muhiimka ah. Samatabbixin iyo daweyn bukaanno aad u xun.
