Terlipressin Acetate oo loogu talagalay Dhiigbaxa Variceal Esophageal
Faahfaahinta Alaabta
| Magaca | N-(N- (N-Glycylglycyl) glycyl) -8-L-lysinevasopressin |
| Lambarka CAS | 14636-12-5 |
| qaacidada molecular | C52H74N16O15S2 |
| Miisaanka molecular | 1227.37 |
| Lambarka EINECS | 238-680-8 |
| Barta karkarinta | 1824.0± 65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.46±0.1 g/cm3 (La saadaaliyay) |
| Xaaladaha kaydinta | Ku hay meel mugdi ah, jawi aan fiicneyn, ku kaydi qaboojiyaha, ka hooseeya -15 ° C. |
| Isku-dhafka aysiidhka | (pKa) 9.90±0.15 (La saadaaliyay) |
La mid ah
[N-α-Triglycyl-8-lysine] -vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine] -vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, terlipressin, terlipressin, terlipressin.
Sharaxaada
Terlipressin, oo magaciisa kiimikaad yahay triglycyllysine vasopressin, waa diyaarinta vasopressin cusub oo muddo dheer shaqaynaysa. Waa nooc ka mid ah dawooyinka, kaas oo aan firfircoonayn laftiisa. Waxaa u dhaqma aminopeptidase in vivo si tartiib tartiib ah "sii daayo" lysine vasopressin firfircoon ka dib markii ay ka saareen saddexda glycyl hadhaaga N-terminus. Sidaa darteed, terlipressin waxay u shaqeysaa sidii kayd kayd ah oo sii daaya lysine vasopressin si joogto ah.
Saamaynta dawooyinka ee terlipressin waa in la isku xidho muruqyada siman ee xididdada dhiigga iyo in la yareeyo socodka dhiigga splanchnic (sida yaraynta socodka dhiigga ee mesentery, beeryarada, ilmo-galeenka, iwm.), taas oo yaraynaysa socodka dhiigga ee portal iyo cadaadiska portal. Dhanka kale, waxay sidoo kale hoos u dhigi kartaa balaasmaha Saamaynta feejignaanta renin, taas oo kordhinaysa socodka dhiigga kelyaha, hagaajinta shaqada kelyaha iyo kordhinta wax soo saarka kaadida ee bukaanka qaba hepatorenal syndrome. Terlipressin hadda waa daawada kaliya ee hagaajin karta heerka badbaadada bukaanada qaba dhiigbaxa hunguriga. Waxaa inta badan loo isticmaalay daawaynta kiliinikada ee dhiigbaxa variceal. Intaa waxaa dheer, terlipressin ayaa sidoo kale si guul leh loogu isticmaalay beerka iyo kelyaha. Guud ahaan, waxay u badan tahay inay door faa'iido leh ka ciyaarto wada noolaanshaha shoogga refractory iyo kicinta wadnaha sambabada. Marka la barbardhigo vasopressin, waxay leedahay saameyn dheer oo joogto ah, ma keento dhibaatooyin halis ah, oo ay ku jiraan fibrinolysis iyo dhibaatooyinka halista ah ee habka wadnaha iyo xididada, waana sahlan tahay in la isticmaalo (mudidda xididka), taas oo ku habboon daryeelka degdega ah iyo halista ah. Badbaadinta iyo daawaynta bukaanada aadka u xanuunsan.
