Linaclotide loogu talagalay xanuunada caloosha iyo mindhicirka 851199-59-2
Faahfaahinta Alaabta
| Magaca | Linaclotide |
| Lambarka CAS | 851199-59-2 |
| qaacidada molecular | C59H79N15O21S6 |
| Miisaanka molecular | 1526.74 |
La mid ah
Linaclotide, Linaelotide Acetate, Linaelotide, CY-14, Liclotide, Argpessin, L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13) -tris(disulfide)
Sharaxaada
Linaclotide, qaab dhismeedka peptide synthetic oo ka kooban 14 amino acids, waxay la xiriirtaa qoyska guanosine peptide endogenous waana daawada kaliya ee FDA-ansixisay GC-C (guanylate) Cyclase-C). C) iyo calool istaagga idiopathic (CIC) ee dadka waaweyn.
Guryaha Kiimikada
Linaclotide waa budo amorphous ah oo cad ilaa cad;wax yar ku milmay biyaha iyo aqueous sodium chloride solution (0.9%).
Sida ay u shaqeyso
Linaclotide waa guanylate cyclase-C agonist receptor (GCCA) oo leh labadaba xanuunka visceral iyo dhaqdhaqaaqa endocrine.Linaclotide iyo dheef-shiid kiimikaadkeeda firfircoon labaduba waxay ku xidhi karaan xajiyaha guanylate cyclase-C (GC-C) ee dusha iftiinka ee epithelium mindhicirka yar.Noocyada xayawaanka, linaclotide waxay yaraynaysaa xanuunka visceral waxayna kordhisaa socodka caloosha iyo mindhicirka iyada oo loo marayo firfircoonida GC-C, iyo bini'aadamka, daroogadu waxay sidoo kale kordhisaa socodka colonic.Natiijada firfircoonida GC-C waxay kordhisay uruurinta unugyada gudaha iyo ka-baxsan cGMP (cyclic guanosine monophosphate).cGMP ka baxsan unugyada waxay yareyn kartaa dhaqdhaqaaqa fiilooyinka dareemayaasha xanuunka waxayna yareyn kartaa xanuunka visceral ee xayawaanka moodada ah.Intracellular cGMP waxay kordhin kartaa dheecaanka chloride iyo bicarbonate ee mindhicirka yar isaga oo dhaqaajiya CFTR (cystic fibrosis transmembrane conductance regulator), taas oo ugu dambeyntii keenta kororka dheecaanka xiidmaha yar yar iyo xawaaraha socodka yar yar ee mindhicirka.
FAQ
Ma dammaanad qaadaysaa keenista badbaado iyo badbaado leh?
Haa, waxaan had iyo jeer isticmaalnaa baakadaha dhoofinta tayada sare leh.Waxaan sidoo kale u isticmaalnaa baakad khatar gaar ah oo loogu talagalay alaabada khatarta ah iyo kuwa rarida kaydinta qaboojiyaha ee la ansixiyey ee walxaha xasaasiga ah ee heerkulka.Baakadaha takhasuska leh iyo shuruudaha xirxirida ee aan caadiga ahayn waxay keeni karaan kharash dheeraad ah.
Ka warran khidmadaha rarida?
Qiimaha dhoofintu wuxuu ku xiran yahay habka aad u dooratay inaad alaabta ku hesho.Express sida caadiga ah waa kan ugu dhaqsaha badan laakiin sidoo kale ugu qaalisan.Gaadiidka badda ayaa ah xalka ugu fiican ee xaddi badan.Qiimaha xamuulka sida saxda ah waxaan ku siin karnaa kaliya haddii aan ogaano faahfaahinta qadarka, miisaanka iyo habka.Fadlan nala soo xidhiidh wixii macluumaad dheeraad ah
