Semaglutide ee Nooca 2 ee Macaanka

Semaglutide waa jiil cusub oo GLP-1 ah (glucagon-like peptide-1) analogs, iyo semaglutide waa qaab qiyaasta qiyaasta muddada-dheer ee lagu sameeyay qaab dhismeedka aasaasiga ah ee liraglutide, kaas oo saameyn wanaagsan ku leh daaweynta nooca 2aad ee sonkorowga.Novo Nordisk waxay dhamaystirtay 6 Wajiga IIIa daraasaadka duritaanada semaglutide, waxayna soo gudbisay codsi cusub oo diiwaan gelinta dawada loogu talagalay cirbadeynta toddobaadlaha ah ee semaglutide Maamulka Cuntada iyo Dawooyinka (FDA) ee Diisambar 5, 2016. Codsiga Ogolaanshaha Suuqgeynta (MAA) ayaa sidoo kale loo gudbiyay Wakaaladda Daawooyinka Yurub (EMA).

Marka la barbardhigo liraglutide, semaglutide waxay leedahay silsilad aliphatic dheer iyo kororka hydrophobicity, laakiin semaglutide waxaa lagu beddelaa silsilad gaaban oo PEG ah, iyo hydrophilicity si weyn ayaa loo wanaajiyey.Beddelka PEG ka dib, ma aha oo kaliya inay ku xidho si dhow albumin, daboolo goobta enzymatic hydrolysis ee DPP-4, laakiin sidoo kale hoos u dhigista kelyaha, sii dheereeyaan nolosha nuska noolaha, iyo gaadho saamaynta wareegga dheer.