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Magaca | Paclitaxel |
Lambarka CAS | 33069-62-4 |
qaacidada molecular | C47H51NO14 |
Miisaanka molecular | 853.92 |
Lambarka EINECS | 608-826-9 |
Barta Karsan | 774.66°C (La saadaaliyay) |
Cufnaanta | 0.200 |
Xaaladda kaydinta | Ku dabool qallalan, ku kaydi qaboojiyaha, 2-8 ° C |
Foomka | Budada |
Midabka | Caddaan |
Baakad | Bac PE+Bacda aluminium |
Paclitaxel HCL; Paclitaxel ( cayriin dabiiciga ah); Paclitaxelx; N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL, TAXUS BREVIFOLIA;PACLITAXEL, TAXUSSPECIES;PACLITAXOL;PACLITAXEL
Sharaxaada
Paclitaxel waa diterpenoid monomeric ah oo laga soo saaro jilif dhirta dabiiciga ah ee daawada Taxus.Baafinta Isotope waxay muujisay in paclitaxel kaliya ay ku xidhan tahay microtubules-ka polymerized oo aanu ka falcelinayn dimers tubulin-ka aan polymerized.Ka dib markii unugyadu ay soo gaadhaan paclitaxel, tiro badan oo microtubules ah ayaa ku urursan doona unugyada.Isku-ururinta microtubules-kan waxay faragelisaa shaqooyinka kala duwan ee unugyada, gaar ahaan qaybta unuggu waxay istaagtaa marxaladda mitirka waxayna xannibaysaa qaybta caadiga ah ee unugyada.Iyadoo loo marayo Ⅱ-Ⅲ cilmi-baaris caafimaad, paclitaxel waxay inta badan ku habboon tahay kansarka ugxan-sidaha iyo kansarka naasaha, sidoo kale waxay leedahay saameyn daweyn ah oo ku saabsan kansarka sambabada, kansarka mindhicirka, melanoma, kansarka madaxa iyo qoorta, lymphoma iyo burada maskaxda.
Tilmaamaha
Waxay saameyn wanaagsan ku leedahay daaweynta kansarka ugxan-sidaha iyo platinum iyo kansarka kale ee ugxan-sidaha iyo kansarka naasaha.Kansarka, kansarka mindhicirka sare, unugyada yaryar iyo kansarka sambabada unugyada aan yareyn waxay leeyihiin aragti wanaagsan.
Isticmaalka
Isticmaal 1: Botanicals-ka-hortagga burooyinka ballaaran ee kansarka ugxan-sidaha, kansarka naasaha, iwm.
Isticmaal 2: botanicals-ka-hortagga burooyinka ballaaran ee daaweynta kansarka ugxan-sidaha, kansarka naasaha iyo cudurrada kale.
Isticmaal 3: Daawooyinka lidka-tumorka.Daawaynta kansarka naasaha ee metastatic iyo kansarka ugxan-sidaha metastatic.Botanicals-ka-hortagga burooyinka ballaaran ee daaweynta kansarka ugxan-sidaha, kansarka naasaha iyo cudurrada kale.
Isticmaal 4: Daawo waxtar leh oo ka hortagga burooyinka;waxay kuxirantahay gobolka N-terminal ee β-tubulin, waxay kor u qaadaa microtubule hore oo xasiloon, waxay ka hortagtaa depolymerization, waxay ka hortagtaa kala qaybinta unugyada caadiga ah iyo dabinka marxaladda G2 / M ee wareegga unugyada.
Isticmaalka 5: Daawada lidka ku ah microtubule, ka hortagga depolymerization iyada oo kor u qaadeysa polymerization tubulin, ilaalinta xasilloonida tuubada, iyo joojinta mitosis unugga.