Chondroitin Sulfate ee Daaweynta Wadnaha Wadnaha, Arthritis-ka iyo Bogsiinta Dhaawacyada Corneal Daahirnimada 98%
Faahfaahinta Alaabta
| Magaca | Chondroitin sulfate |
| Lambarka CAS | 9007-28-7 |
| qaacidada molecular | C13H21NO15S |
| Miisaanka molecular | 463.36854 |
| Lambarka EINECS | 232-696-9 |
| Biyuhu milma | Biyo ku milmay |
| daahirnimo | 98% |
| Kaydinta | Ku kaydi heerkul joogto ah |
| Foomka | Budada |
| Midabka | Cadaan ilaa caddaan |
| Baakad | Bac PE+Bacda aluminium |
La mid ah
poly-1 (2/3) -n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4- (6) sulfonyl-d-galactose;chondroitinpoly sulfate;chondroitin sulfates;chondroiti nsulfuric acid;chondroitin sulfuric acids;chonsurid;CSO;(5ξ)-2-(Carboxyamino) -2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Saamaynta Dawaynta
Sharaxaada
Chondroitinsulfate (CS) waa mucopolysaccharide acidic ah oo laga soo saaray lagana sifeeyay unug carjawda xayawaanka.Chondroitin sulfate waxa uu leeyahay qaabab kala duwan sida A, C, D, E, H iyo K. 36% ilaa 39%), unugyo kale sida lafaha lugaha, seedaha, maqaarka, lafaha, iwm ayaa sidoo kale ku jira.Waxa ku jira carjawda kalluunku aad bay hodan u tahay, sida 50% ilaa 60% ee lafaha shark, iyo wax aad u yar oo ku jira unugyada isku xidha.
Cudurada halbowlaha wadnaha, kor u kaca dufanka dhiigga iyo kolestaroolka, arteriosclerosis, angina pectoris, ischemia myocardial ischemia, wadnaxanuun myocardial, iwm ee bukaanka qaba cudurrada wadnaha.
Falka dawooyinka
Rapamycin (RAPA) waxay leedahay waxyeellooyin la mid ah FK506.Tiro badan oo tijaabo caafimaad ah, waxyeelooyinkeeda ayaa lagu ogaaday inay yihiin kuwo ku tiirsan qiyaasta iyo dib-u-celinta, RAPA-da qiyaasaha daweynta looma helin in ay leedahay nephrotoxicity muhiim ah oo aan lahayn hyperplasia cirridka.Sunta ugu weyn iyo dhibaatooyinka soo raaca waxaa ka mid ah: madax-xanuun, lallabbo, madax-wareer, dhiig-bax sanka, iyo xanuunka kala goysyada.Dhibaatooyinka shaybaarka waxaa ka mid ah: thrombocytopenia, leukopenia, hemoglobin hooseeya, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, enzymes beerka oo sarreeya (SGOT, SGPT), dehydrogenase lactate sare, hypokalemia, Hypomagnesemia, iwm. Heerarka fosfooraska balaasmaha ayaa loo maleynayaa inay dheertahay soo saarista fosfatka ee kelyaha la tallaalay iyadoo la adeegsanayo daawaynta difaaca jirka ee RAPA.Sida kuwa kale ee difaaca jirka ah, RAPA waxay leedahay fursad sii kordhaysa oo ah infekshanka, iyada oo la soo sheegayo inay u janjeerto inay kordhiso oof wareenka gaar ahaan, laakiin dhacdooyinka caabuqyada kale ee fursada ah aad ugama duwana CsA.
Saamaynta Sunta
Chondroitin sulfate waxay si ballaaran ugu jirtaa unugyada carjawda aadanaha iyo xayawaanka.Diyaarinta daawadu waxay inta badan ka kooban tahay laba isomers ee chondroitin sulfate A iyo chondroitin sulfate C, iyo waxa ku jira chondroitin sulfate ee carjawda xayawaanka ee noocyada iyo da'aha kala duwan waa kala duwan yihiin.Saameynteeda dawooyinka waa sida soo socota: chondroitin sulfate waxay ka saari kartaa lipids iyo lipoproteins ee dhiigga, waxay ka saartaa kolestaroolka xididdada dhiigga ee wadnaha, ka hortagga iyo daaweynta atherosclerosis, waxayna kordhisaa heerka beddelka dufanka iyo asiidhyada dufanka leh ee unugyada.Chondroitin sulfate waxay si wax ku ool ah uga hortagi kartaa una daweyn kartaa cudurada wadnaha.Waxay leedahay anti-atherosclerosis iyo saamaynta samaynta huurada anti-atherogenic ee moodooyinka arteriosclerosis ee tijaabada ah;waxay kordhisaa laamaha halbowlaha ama wareegga dammaanadda ee atherosclerosis, waxayna soo dedejin kartaa tijaabada halbowlayaasha halbowlayaasha wadnaha ama embolism.Bogsiinta, dib-u-soo-nooleynta iyo hagaajinta necrosis-ka myocardial ama xumaanshaha.Waxay kordhin kartaa biosynthesis ee Messenger-ka ribonucleic acid (mRNA) iyo deoxyribonucleic acid (DNA) waxayna leedahay saamaynta kor u qaadida dheef-shiid kiimikaadka unugyada.Dhaqdhaqaaqa xinjirowga lidka ku ah oo hooseeya.Chondroitin sulfate waxay leedahay saameyn dhexdhexaad ah oo ka hortag ah, iyo 1 mg oo chondroitin sulfate A waxay u dhigantaa waxqabadka xinjirowga lidka ku ah ee 0.45U ee heparin.Dhaqdhaqaaqa xinjirowga lidka ku ah kuma xirna antithrombin III inuu doorkiisa ciyaaro, wuxuu sameyn karaa firfircoonida xinjirowga lidka ku ah iyada oo loo marayo nidaamka fibrinogen.Chondroitin sulfate sidoo kale waxay leedahay anti-bararka, bogsiinta boogaha degdega ah iyo saamaynta ka hortagga burooyinka.
