Paclitaxel 33069-62-4 Dawooyinka Botanical buro-burada ee kansarka ugxan-qaarka, kansarka naasaha

Sifo

PACLitaxel waa monomenoid ditepenoid digaag laga soo saaray jilif ee caagagga cashuurta ee dabiiciga ah. Raadinta raadadka ayaa muujisay in PACLitaxel kaliya ay ku xidhan tahay microtubles-ka busta-ka-baxa oo aan ka falcelin caloosha aan loo baahnayn. Ka dib markii unugyada ay u soo gaadhaan Paclitaxel, tiro badan oo ka mid ah microtubules ayaa lagu ururin doonaa unugyada. Ururinta microtubuless-yada waxay farageliyaan howlo kala duwan oo unugyada ah, gaar ahaan qeybinta unugyada waxay joogsadaan wajiga mitatic-ka waxayna xannibtaa qeybta caadiga ah ee unugyada. Iyada oo loo marayo ⅱ-ⅲ Cilmi baarista caafimaad, PACLitaxel inta badan waxay ku habboon tahay kansarka ugxansidaha iyo kansarka naasaha, waxayna sidoo kale saameyn xun ka qabaan kansarka sanbabada, kansarka wejiga, kansarka melanoma, madaxa iyo qoorta iyo burooyinka maskaxda.

Astaamaha

Waxay saameyn wanaagsan ku leedahay daaweynta cudurka kansarka ugxansidaha iyo platinum iyo kansarka kale ee loo yaqaan 'ovilatior' iyo kansarka naasaha. Kansarka, kansarka sare ee caloosha, kansarka yar yar ee unugyada yar yar iyo kan aan yar ahayn ee kansarka sanbabka ayaa leh aragti wanaagsan.

Adeegsiga

Adeegso 1: Bogagga ballaaran ee loo yaqaan 'anti-buro' ee loo yaqaan 'botanicals' ee loogu talagalay kansarka ugmata, kansarka naasaha, iwm.

Isticmaal 2: Broad-Spectrum-Tumbom Toonicals ee loogu talagalay daaweynta kansarka ugrada, kansarka naasaha iyo cudurada kale.

Isticmaal 3: dawooyinka ka hortaga lidka ku dhaca. Daaweynta kansarka naasaha ee metastatic-ka iyo kansarka metastatic-ka ah. Botanical-ka ballaaran ee loo yaqaan 'tromi-buro' ee loo yaqaan 'botanicals' ee loo yaqaan 'potanacals' ee loogu talagalay daaweynta kansarka ugxan-qaarka, kansarka naasaha iyo cudurada kale.

Adeegso 4: daroogada ka hortagga burada ee wax ku oolka ah; Ku xidhnaada gobolka-terminal ee β-tuppulin, waxay kor u qaadaa qaab-dhismeedka microtaubile ee aadka u deggan, waxay ka hortagtaa qaybta unugyada caadiga ah iyo dabinnada ee wareega g2 / m wareega wareega g2 / m ee wareega wareega.

Isticmaal 5: Daroogada anti-microtaubulubule, oo xakameynaya soo-saarista hoos udhaca ah adoo dhiirrigelinaya poluman-ka polimping polimon, dayactirka xasilloonida tudunta, iyo in lagu xannaaneeyo mimitosis unugyada.