Carbetocin si ay uga hortagto foosha Uterine-ka iyo Dhiig-baxa dhalmada ka dib
Faahfaahinta Alaabta
| Magaca | CARBETICIN |
| Lambarka CAS | 37025-55-1 |
| qaacidada molecular | C45H69N11O12S |
| Miisaanka molecular | 988.17 |
| Lambarka EINECS | 253-312-6 |
| Wareegid gaar ah | D -69.0° (c = 0.25 in 1M acetic acid) |
| Barta karkarinta | 1477.9±65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.218±0.06 g/cm3 (La saadaaliyay) |
| Xaaladaha kaydinta | -15°C |
| Foomka | budo |
La mid ah
BUTYRYL-TYR(Aniga)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(Aniga)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; KAARBETOCIIN; CARBETOCINTRIFLUOROACETATESALAT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Dhaqdhaqaaqa noolaha
Carbetocin, analoogga oxytocin (OT), waa agonist receptor oxytocin leh Ki of 7.1 nM. Carbetocin waxay leedahay xiriir sare (Ki = 1.17 μM) ee kimeric N-terminus ee qaboojiyaha oxytocin. Carbetocin waxay awood u leedahay cilmi-baarista dhiig-baxa dhalmada ka dib. Carbetocin waxay geli kartaa xannibaadda maskaxda-maskaxda waxayna leedahay firfircooni ka hortagga niyad-jabka oo kale iyada oo hawlgelinaysa soo-qabayaasha oxytocin ee CNS.
Shaqada
Carbetocin waa oxytocin 8-peptide analoog ah oo muddo dheer shaqaynaysa oo leh guryaha agonist, iyo alaabteeda caafimaad iyo dawooyinku waxay la mid yihiin kuwa dabiiciga ah ee oxytocin. Sida oxytocin, carbetocin waxay ku xidhan tahay soo-dhoweeyayaasha hoormoonka ee muruqa siman ee ilmo-galeenka, taasoo keenta qandho laxan ee ilmo-galeenka, kordhinta inta jeer iyo kordhinta codka ilmo-galeenka iyada oo ku saleysan foosha asalka ah. Heerarka soo-dhoweynta Oxytocin ee ilmo-galeenka ayaa ku hooseeya xaaladda aan uurka lahayn, korodhka xilliga uurka, iyo heerka ugu sarreeya xilliga foosha. Sidaa darteed, karbetocin wax saameyn ah kuma laha ilmo-galeenka aan uurka lahayn, laakiin waxay leedahay saameyn xoog leh oo qanjidhada ilmo-galeenka ah ee ilmo-galeenka uurka leh iyo ilmo-galeenka cusub ee la soo saaray.
Beddel kontaroolada
Isbedelada waxaa lagu xakameynayaa habraaca. Iyada oo ku saleysan saameynta iyo khatarta iyo darnaanta, isbeddelada waxaa loo kala saaraa sida Weyn, Yar iyo Goobta. Isbeddellada goobta ayaa saameyn yar ku leh badbaadada iyo tayada badeecada, sidaas darteed uma baahna oggolaansho iyo ogeysiin macaamiisha; Isbeddellada yaryar waxay saameyn dhexdhexaad ah ku leeyihiin badbaadada iyo tayada alaabta, waxayna u baahan yihiin in la ogeysiiyo macaamilka; Isbeddellada waaweyn ayaa saameyn sare ku leh badbaadada iyo tayada badeecada, waxayna u baahan yihiin oggolaansho macmiilka.
Marka loo eego nidaamka, xakamaynta isbeddelka ayaa lagu bilaabaa codsiga isbeddelka kaas oo faahfaahinta isbeddelka iyo macquulka ah ee isbeddelka lagu qeexay. Qiimaynta ayaa markaa la sameeyaa ka dib codsiga, kaas oo lagu sameeyo xakamaynta isbeddelka waaxaha khuseeya. Dhanka kale, kantaroolka isbeddelka waxaa loo kala saaray heerka sare, heerka guud iyo heerka hoose. Ka dib qiimaynta ku haboon iyo sidoo kale kala soocida, dhammaan xakamaynta isbeddelka heerka waa in uu ansixiyo Maareeyaha QA. Xakamaynta isbeddelka waxa la fuliyaa oggolaanshaha ka dib si waafaqsan qorshe hawleedka. Xakamaynta isbeddelka ugu dambayntii waa la xidhay ka dib markii QA ay xaqiijiso in xakamaynta isbeddelka si habboon loo hirgeliyey. Haddii ay ku lug leedahay ogeysiinta macmiilka, macmiilka waa in lagu wargeliyaa wakhti ku habboon ka dib markii la oggolaaday xakamaynta isbeddelka
