Rapamycin waa daroogo is-dhaafsiga, ka hortagga kansarka iyo ka hortagga gabowga

Sifo

Rapamycin waa antibiyootig macrotide ah oo qaab ahaan u la mid ah astarofol (FK506), laakiin waxay leedahay hab is-beddel aad u kaladuwan. FK506 waxay horjoogsataa faafitaanka T0 wejiga G0 ee wejiga G1, halka RAPA Blocks Scraseports-ka oo kaladuwan iyo unugyada kale ee G1-ka ee ku-tiirsanaanta '' G1506 '. Jaamacayaasha cilmi-baaristayaasha caafimaad ee Jaamacadda Chicago waxay u adeegsadaan kiniiniyada 'Rapamycin' oo kale oo ay ka heleen casiirka Grappefruit si loo daweeyo Melanoma, Mareykanka, oo si weyn u horumarin kara saameynta dawooyinka dawooyinka lagu daweeyo ee dawooyinka kale ee dawooyinka, oo ay sii dheertaan jiritaanka jiritaanka jiritaanka waqtiga bukaanka. Daraasaduhu waxay muujiyeen in rapamycin si fudud loo go'ay enzymes ka dib markii uu soo galay mareenka dheef-shiidka, iyo casiir canab ah oo aad u badan oo ay ka hortagi karto saamaynta burburka ee qulqulka dheef-shiidka ee ku yaal Rapamycins. Waxay hagaajin kartaa bioavaulability ee rapamycin. Waxaa la sheegay in dhakhaatiirtii hore ee Holland ay ogaadeen in casiir canab ah ay leedahay in la wanaajiyo wanaajinta afka ah ee xirashada shirkadda Yurub iyo kuwa Mareykanka ah ay ka codsadeen diyaarinta Rapamycin.

Sanadihii la soo dhaafay, daraasaduhu waxay ogaadeen in bartilmaameedka Rapamycin (Mtor) uu yahay kinarelllular kinase, iyo si aan caadi ahayn oo jidka loo maro waxay ku kicin kartaa cudurro kala duwan. Maaddaama la bartilmaameedsanayo in la xakameeyo Mortor, Rapamycin-ka wuxuu ku daaweyn karaa burooyinka si dhaw ula ah jidkaan, oo ay kujirto kansarka kiraysiga, kansarka sanbabada, kansarka naasaha, kansarka naasaha, kansarka naasaha, kansarka dareeraha ah iyo kansarka cagaaran. Gaar ahaan daaweynta laba cudur oo naadir ah, lam (Lymfangiomyomatosis) iyo TSC (TSBEROus Sclerosis), saameynta ayaa sidoo kale ah in la caddeeyo, iyo TSC sidoo kale waxaa loo tixgelin karaa cudurada burada illaa xad.

Saamaynta dhinaca

Rapamycin (RAPA) waxay leedahay waxyeelo la mid ah FK506. Tiro badan oo tijaabooyin caafimaad ah, waxyeellooyinkeeda waxaa loo ogaaday in lagu kalsoonaan karo oo la beddeli karo, iyo rapa ee qaddarka daweynta aan la helin inay leeyihiin nivrotoxicity weyn oo aan lahayn gitivalplasia. Waxyeelooyinka sunta ah ee ugu weyn iyo kuwa muuqata waxaa ka mid ah: madax xanuun, lallabbo, dawakh, sanka, sanka, iyo xanuun wadajirka ah. Sinaan-qabadyada sheybaarka waxaa ka mid ah: Twrbortytopenia, Tuuloglobin, Hypertriglycemia, hypercholetemia, hypercholeemia, hypergholemia, hypergremia, hypokagnemia, iwm. Sababta heerarka plasma ee hoose ee plasphate-ka ayaa loo maleynayaa inay ka soo baxaan fosfooraska fosfooraska fosfooraska ah ee kelyaha lagu tallaalaa ee ku saleysan daaweynta daweynta tallaalka ku saleysan. Sida kuwa kale ee Immumpsersers, RAPA waxay leedahay fursad kordha oo ah infekshan, oo ay weheliso in lagu kordhiyo oof-wareenka gaar ahaan, laakiin dhacdooyinka infekshannada kale ee faa iidada leh si weyn ugama aysan duwanaanin CSA.