Magac | Ganirelix acetate |
Lambarka CAS | 12324-29-7 |
Qaaciddada molika | C30h11cln18O13 |
Miisaanka Moleculal | 1570.34 |
Ac-dnal-dcpa-dpal-sery-tyr-dhar-dhaar Ganirelix; Ganirelix acetate USP / EP /
Ganirelix waa jahwareerka isku-darka isku-darka, iyo cusbada acetate, ganirelix acetate waa hoormooyin-ka-sii-daynta hoormoonka (GNRH) ee 'GNRH'). Isku xigxiga amino acid waa: ac-d-2nal-d-4pal-d-3pal-sery-d-homaarg (9,10-et2) -Qaar-l-homaarg (9,10-etho-d- alaar-nh2) -pro-d- ala-nh2. Inta badan caafimaad ahaan, waxaa loo isticmaalaa dumarka inay ku sii socdaan barnaamijyada kobcinta tikniyoolajiyadda taranka ee la xakameynayo si looga hortago in lagu yareyo hoormoonka oo loo yaqaan 'hammone' iyo in lagu daaweeyo ciladaha bacrinta sababa. Daroogada ayaa leh astaamaha falcelinta ka xun, heerka uurka ee aadka u sareeya iyo waqtiga daaweynta oo gaaban, oo uu leeyahay faa'iidooyin muuqda marka la barbar dhigo dawooyin la mid ah.
Siidaynta plassile ee hoormoonka 'gonodotoprine' (GNRH) waxay kicisaa isku-darka isku-darka iyo dheecaanka LH iyo FSH. Soo noqnoqda ee LH-yada Lh ee bartamihii iyo soo daahay ee wejiyada dambe ee Foosha waa qiyaastii 1 saacaddiiba. Duufaanni waxay ka muuqdaan ku-meel-gaadhka ku dhaca Serum Lh. Intii lagu gudajiray muddada caadada, siideynta weyn ee GNRH waxay keentaa in Lh. Cudurkii dhexe ee Lh ee 'Morttenthol Lh' ayaa kicin kara dhowr jawaabood oo jir ahaaneed, oo ay ku jiraan: ugxansida, iooist meiois, iyo sameynta coitus-ka. Samaynta heesaha Corpus ayaa sababa heerarka Serum Progesterone-ka si ay u kacaan, halka heerarka empladiol ay dhacaan. Ganirelix acetate waa nin ka hortag ah oo ka hortaga GNRH kaasoo si tartan ah uga horjoogsanaya soo-dhoweynta GNRH ee ku saabsan golaitary gownadotrophs iyo wadiiqooyinka ku xiga ee wareejinta. Waxay soo saartaa deg deg, xakamayn la beddeli karo ee dheecaanka gownodotropin. Saamaynta xannibaadda ganirelix acetate ee dheecaanka 'pisitary lh' ayaa ka xoog badnaa FSH. Ganirelix acetate ayaa ku guuldareystay inuu ku dhiirrigeliyo siideynta koowaad ee loo yaqaan 'endogenous gononorotroprins', oo la jaan qaadaya ka soo horjeedda. Soocelin dhameystiran oo ku saabsan pitutrary Lh iyo heerarka FSH ayaa dhacay 48 saacadood gudahood kadib markii ganirelix acetate la joojiyay.