Ganirelix Acetate Peptide API
Faahfaahinta Alaabta
| Magaca | Ganirelix Acetate |
| Lambarka CAS | 123246-29-7 |
| qaacidada molecular | C80H113ClN18O13 |
| Miisaanka molecular | 1570.34 |
La mid ah
Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/
Sharaxaada
Ganirelix waa xarun decapeptide synthetic, iyo cusbada acetate, Ganirelix acetate waa gonadotropin-sii daynta hormoonka (GnRH) antagonist. Tixda amino acid waa: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Inta badan bukaan-socod ahaan, waxaa loo adeegsadaa haweenka ku jira tignoolajiyada taranka ee la kaalmeeyay barnaamijyada kicinta ugxan-sidaha si looga hortago heerka ugu sarreeya hoormoonka luteining-ka iyo in lagu daweeyo cilladaha bacriminta sababtan awgeed. Daroogadu waxay leedahay sifooyinka falcelinta xun xun, heerka uurka sare iyo muddada daawaynta gaaban, oo uu leeyahay faa'iidooyin cad marka la barbar dhigo daawooyinka la mid ah ee dhaqanka kiliinikada.
Falka dawooyinka
Sii daynta garaaca wadnaha ee hormoonka gonadotropin-sii daaya (GnRH) waxay kicisaa isku-darka iyo dheecaanka LH iyo FSH. Inta jeer ee garaaca garaaca wadnaha ee bartamaha iyo dambe ee follicular waa qiyaastii 1 saac. garaaca wadnaha ayaa ka muuqda kor u kaca ku meel gaadhka ah ee serum LH. Inta lagu jiro xilliga caadada badhtamaha, siidaynta wayn ee GnRH waxay sababtaa kor u kaca LH. Koritaanka LH ee dhexdhexaadka ah wuxuu kicin karaa dhowr jawaabo nafsiyeed, oo ay ku jiraan: ugxansidaha, dib u soo celinta oocyte meiotic, iyo samaynta corpus luteum. Samaynta luteum corpus waxay keentaa in heerka serum progesterone uu kordho, halka heerarka estradiol hoos u dhaco. Ganirelix acetate waa GnRH antagonist kaas oo si tartan ah u xannibaya soo-dhoweynta GnRH ee gonadotrophs ee pituitary iyo dariiqooyinka beddelka ee xiga. Waxay soo saartaa xannibaad degdeg ah, dib-u-noqosho ah ee dheecaanka gonadotropin. Saamaynta xannibaadda ee ganirelix acetate ee dheecaanka pituitary LH ayaa ka xoog badnaa tan FSH. Ganirelix acetate waxay ku guuldareysatay inay kiciso sii deynta ugu horeysa ee gonadotropins endogenous, oo la socota antagonism. Soo kabashada buuxda ee heerarka LH pituitary iyo FSH ayaa dhacay 48 saacadood gudahood ka dib markii ganirelix acetate la joojiyay.
