Daptomycin 103060-53-3 ee Cudurada Faafa
Faahfaahinta Alaabta
| Magaca | Daptomycin |
| Lambarka CAS | 103060-53-3 |
| qaacidada molecular | C72H101N17O26 |
| Miisaanka molecular | 1620.67 |
| Lambarka EINECS | 600-389-2 |
| barta dhalaalaysa | 202-204°C |
| Barta karkarinta | 2078.2± 65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.45±0.1 g/cm3 (La saadaaliyay) |
| Barta toosan | 87℃ |
| Xaaladaha kaydinta | Ku dabool qallalan, ku kaydi qaboojiyaha, ka hooseeya -20 ° C |
| Solubility | Methanol: milma 5mg/ml |
| Isku-dhafka aysiidhka | (pKa) 4.00±0.10 (La saadaaliyay) |
| Foomka | budo |
| Midabka | aan midab lahayn oo huruud ah |
La mid ah
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-] -cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4- (2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-] -cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-] -3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a-glutamyl-a,2-diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Sharaxaada
Antibiyootiga daptomycin waa antibiyootig wareeg ah oo lipopeptide ah oo leh qaab dhismeed cusub oo laga soo saaray maraq halsano ee Streptomyces (S. reseosporus), taas oo caqabad ku ah biosynthesis ee gidaarka unugyada bakteeriyada peptidoglycan iyadoo dhibaysa gaadiidka amino acids ee xuubka unugyada.Beddelidda sifooyinka xuubka cytoplasmic waxay carqaladeyn kartaa shaqada xuubka bakteeriyada siyaabo badan waxayna si degdeg ah u dishaa bakteeriyada Gram-positive.Marka lagu daro awoodda ay u leedahay in ay ku dhaqdo inta badan bakteeriyada Gram-positive, daptomycin waxay aad muhiim ugu tahay noocyada go'doonsan ee muujiyay caabbinta methicillin, vancomycin, iyo linezolid in vitro.Waxay leedahay firfircooni xoog leh, hantidana waxay leedahay saameyn caafimaad oo aad muhiim u ah bukaannada aadka u buka ee cudurka qaba.Eosinophilic pneumonia waa cudur naadir ah oo aad halis u ah oo leh astaamo ay ka mid yihiin qandho, qufac, neefsasho, iyo neefsashada oo ku adkaata.
Saamaynta Ka-hortagga bakteeriyada
Daptomycin waxay leedahay firfircooni bacteriostatic oo wanaagsan oo lid ku ah bakteeriyada kala duwan ee u adkaysata antibiyootiga, sida MIC=0.06-0.5 μg/ml oo loogu talagalay Staphylococcus aureus u adkaysta methicillin (MRSA), iyo Staphylococcus aureus u adkaysta methicillin (MRSA).MIC=0.0625～1μg/ml ee bakteeriyada, MIC=0.12～0.5μg/ml ee oxacillin u adkaysta Staphylococcus epidermidis, MIC=2.5μg/ml Enterococcus waa 0.5-1μg/ml, MIC-ga Enterococcus ee u adkaysata antibiyootiga glycopeptide waa 1-2μg/ml.
