Caspofungin ee caabuqyada Antifungal
Faahfaahinta Alaabta
| Magaca | Caspofungin |
| Lambarka CAS | 162808-62-0 |
| qaacidada molecular | C52H88N10O15 |
| Miisaanka molecular | 1093.31 |
| Lambarka EINECS | 1806241-263-5 |
| Barta karkarinta | 1408.1± 65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.36±0.1 g/cm3 (La saadaaliyay) |
| Isku-dhafka aysiidhka | (pKa) 9.86±0.26 (La saadaaliyay) |
La mid ah
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1-[(4R,5S) -5-[(2-aMinoethyl) aMino]-N2-(10,12-diMethyl-1-oxotetradecyl) -4-hydroxy- L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Guryaha Kiimikada
Caspofungin wuxuu ahaa echinocandin-kii ugu horreeyay ee loo oggolaaday daaweynta cudurrada fangas-ka-soo-baxa.In vitro iyo in vivo tijaabooyin ayaa xaqiijiyay in caspofungin uu leeyahay firfircooni bakteeriyada wanaagsan ka dhanka ah pathogene-fursad muhiim ah - Candida iyo Aspergillus.Caspofungin wuxuu dillaacin karaa derbiga unugga isagoo xakameynaya isku-darka 1,3-β-glucan.Kiliinik ahaan, caspofungin waxay saameyn wanaagsan ku leedahay daaweynta candidiasis kala duwan iyo aspergillosis.
Saamaynta
(1,3) -D-glucan synthase waa qayb muhiim ah oo ka mid ah isku-darka unugyada fangas ee unugyada fangas, iyo caspofungin waxay sameyn kartaa saameyn antifungal ah iyada oo aan si tartan ah u joojinayn ensaymkan.Ka dib maamulka xididada, fiirsashada daawada balasmaha ayaa si degdeg ah hoos ugu dhacda sababtoo ah qaybinta unugyada, oo ay ku xigto si tartiib tartiib ah daawada ka soo baxa unugyada.Dheef-shiid kiimikaad ee caspofungin ayaa kordhay iyadoo la kordhinayo qiyaasta qiyaasta waxayna la xiriirtaa qiyaasta waqtiga si loo xasilo oo leh qiyaaso badan.Sidaa darteed, si loo gaaro heerar daaweyn oo wax ku ool ah oo looga fogaado ururinta daroogada, qiyaasta ugu horreysa ee rarista waa in la maamulaa oo ay ku xigto qiyaasta dayactirka.Markaad isticmaasho cytochrome p4503A4 inducers isku mar, sida rifampicin, carbamazepine, dexamethasone, phenytoin, iwm, waxaa lagu talinayaa in la kordhiyo qiyaasta dayactirka ee caspofungin.
Tilmaamaha
Tilmaamaha FDA-ansixisay ee Caspofungin waxaa ka mid ah: 1. Qandho leh neutropenia: lagu qeexay sida: qandho> 38°C oo leh tirada neutrophils ee buuxa (ANC) ≤500/ml, ama ANC ≤1000/ml waxaana la saadaaliyay in la dhimi karo ka hooseeya 500/ml.Marka loo eego talada Ururka Cudurrada Faafa ee Ameerika (IDSA), inkasta oo bukaannada qaba qandhada joogtada ah iyo neutropenia lagu daaweeyay antibiyootiko ballaaran, bukaannada khatarta sare leh ayaa weli lagula talinayaa inay isticmaalaan daaweynta antifungal ee empiric, oo ay ku jiraan caspofungin iyo daawooyinka kale ee antifungal. ..2. Candidiasis Invasive: IDSA waxay ku talinaysaa echinocandins (sida caspofungin) sida dawada doorashada ee candidemia.Waxa kale oo loo isticmaali karaa in lagu daweeyo nabarrada caloosha ku jira, peritonitis iyo caabuqyada laabta ee uu keeno caabuqa Candida.3. Candidiasis Esophageal: Caspofungin waxaa loo isticmaali karaa in lagu daaweeyo candidiasis hunguriga ee bukaanka qaba diidmo ama dulqaad la'aanta daaweynta kale.Daraasado dhowr ah ayaa lagu ogaaday in saameynta daaweynta caspofungin ay la mid tahay tan fluconazole.4. Aspergillosis invasive: Caspofungin ayaa loo oggolaaday daawaynta aspergillosis-ka-soo-baxa ee bukaannada qaba dulqaad-xumada, caabbinta, iyo waxtar la'aanta daawada ugu weyn ee antifungal, voriconazole.Si kastaba ha ahaatee, echinocandin laguma talinayo daaweynta safka hore.
