Caspofungin oo loogu talagalay infekshannada ka hortaga
Si faahfaafo
| Magac | Caspindin |
| Lambarka CAS | 162808-62-0 |
| Qaaciddada molika | C52h88n10o15 |
| Miisaanka Moleculal | 1093.31 |
| Tirada EINECS | 1806241-263-5 |
| Point karkaraya | 1408.1 ± 65.0 ° C (saadaaliyay) |
| Cucid | 1.36 ± 0.1 g / cm3 (saadaaliyay) |
| Isutirka aashitada | (PKA) 9.86 ± 0.26 (saadaaliyay) |
Ereyo isku mid ah
CS-1171; Caspofund; Caspofune; castfubfinin; pneumoctonblinb0,1 - [(4s, [(2-aminotyl) aminols -n2- ((10,12-damthyl) -1-oxotetradecyl) -4-hydroxy-L-Ornithine] -5 - [3R) -3-3-Hydroxy-L-Ornituntund-L-Ornituntund-L-Ornituntundinm-L-Ornituntund-L-ornitundinMinmk-0991, Aids058650. AIDS-058650
Sifooyinka kiimikada
Caspofungin wuxuu ahaa Echinonownd-kii ugu horreeyay ee loo oggolaaday daaweynta cudurada fangaska ee lagu baro. Vitro iyo tijaabooyinka Vivo waxay xaqiijiyeen in Caspofungin uu leeyahay wax qabad bakteeriyada oo ka hortaga bakteeriyada oo ka dhan ah cudurka ceyriyada sicirka ah iyo Aspergillus. Caspofungin wuxuu dillaaci karaa derbiga qolka isagoo xakameynaya isku-darka 1,3-β-Glucan. Caafimaad ahaan, castungin waxay saameyn wanaagsan ku leedahay daaweynta caasinimada kala duwan iyo astonpillosis.
Saamayn
(1,3) -D-Glucan Synthase Spanthes waa qayb muhiim ah oo ka mid ah synthesis-ka-furka ee fungal, iyo castununun-ka wuxuu ka saari karaa saameynta ka hortagga ah ee aan si tartan ah uga horjoogsanayn enzyme-ka. Ka dib maamulka xididada ee xildhibaanka, uruurinta daroogada plasma-ka ayaa si dhakhso leh u dhibbanaysa qaybinta unugyada, oo ay ku xigto daroogada tartiib tartiib ah ee daroogada unugyada. Dheef-shiid kiimikaadka Caspofungin ayaa kordhay iyada oo la kordhiyo qiyaasta kordhinta qaddarka waxayna ahayd qaddarka laxiriira waqtiga si joogto ah loo sii wado dowlad joogto ah oo leh qiyaaso badan. Sidaa darteed, si loo gaaro heerar ku-meel-gaar ah oo wax ku ool ah oo looga fogaado uruurinta daroogada, qiyaasta xamuulka ee ugu horreeya waa in la qaataa cabir dayactir ah. Markii la adeegsanayo cytochrome p4503a4 waa tusaalooyin isku mid ah, sida rifazicin, carbasazeine, dexamistasone, Dexamethone, PHAMETEIN, PHENTOIN, iwm.
Astaamaha
Tilmaamaha FDA ee loo yaqaan 'Caspofungin' ee Caspofundin waxaa ka mid ah: 1. Qandho leh Neutropenia: Qandho> 38 ° C oo leh engetophil tirinta (ML ≤500 / ml, ama ml ≤1000 iyo in la dhimi karo ka hooseeya 500 / ml. Marka loo eego soo-jeedinta cudurada faafa ee Mareykanka (IDSA), in kasta oo bukaannada qaba qandhada joogtada ah iyo bukaannada halista badan lagu daweeyo in lagu isticmaalo daweynta antifuncal, oo ay ku jiraan dawooyinka ka hortaga cufnaanta, oo ay ku jiraan dawooyinka kale ee kantaroolka ah. . 2. Canchisisis-ka ku-dhejiska: IDSA waxay ku talineysaa Echinocations (sida Caspofungind) sida daroogada doorashada ee caleemaha. Waxaa sidoo kale loo isticmaali karaa in lagu daweeyo farqiga udhaca caloosha, peritonitis iyo infakshannada feeraha oo ay sababaan infekshanka candida. 3. Dhowr daraasadood ayaa la ogaaday in saameynta daweynta ee castungihin ay u dhigantaa shaashadda fluconazole. 4. Cassporgillosis: Caspofungin waxaa loo oggolaaday daaweynta astpergilosis-ka bukaanka ee loo dulqaadan karo dulqaad, iska caabin, iyo wax-u-soo-celin daroogada antifganta ah, rericonazole. Si kastaba ha noqotee, Echinocandun laguma talinayo sida daaweynta-koowaad.
