Atosiban Acetate Loo Isticmaalay Dhalashada Ka Hortagga Ah
Faahfaahinta Alaabta
| Magaca | Atosiban |
| Lambarka CAS | 90779-69-4 |
| qaacidada molecular | C43H67N11O12S2 |
| Miisaanka molecular | 994.19 |
| Lambarka EINECS | 806-815-5 |
| Barta karkarinta | 1469.0± 65.0 °C (La saadaaliyay) |
| Cufnaanta | 1.254±0.06 g/cm3 (La saadaaliyay) |
| Xaaladaha kaydinta | -20°C |
| Solubility | H2O: ≤100 mg/ml |
Sharaxaada
Atosiban acetate waa polypeptide wareeg ah oo disulfide ku xidhan oo ka kooban 9 amino acids. Waa molecule oxytocin oo la bedelay ee boosaska 1, 2, 4 iyo 8. N-terminus ee peptide waa 3-mercaptopropionic acid (thiol iyo Kooxda sulfhydryl ee [Cys] 6 waxay sameeyaan dammaanad disulfide ah), C-terminal waxay ku jirtaa qaabka amide, amino acid labaad ee la beddelay ee N-terminal. [D-Tyr (Et)]2, iyo atosiban acetate waxaa loo isticmaalaa daawooyinka sida khalka Waxay u jirtaa qaab milix ah, oo loo yaqaan 'atosiban acetate'.
Codsiga
Atosiban waa oxytocin iyo vasopressin V1A isku-dhafan oo ka soo horjeeda soo-dhoweeyaha, oxytocin reseptor wuxuu qaab ahaan la mid yahay xajiyaha vasopressin V1A. Marka la xidho reseptor-ka oxytocin, oxytocin wali wuu ku dhaqmi karaa iyada oo loo marayo soo-dhoweeyaha V1A, markaa waa lagama maarmaan in la xannibo labada dariiq ee kor ku xusan isku mar, iyo hal lid ku ah hal reseptor ayaa si wax ku ool ah u joojin kara foosha ilmo-galeenka. Tani sidoo kale waa mid ka mid ah sababaha ugu muhiimsan ee agonistayaasha β-receptor, kaalshiyamka kanaalka kaalshiyamka iyo prostaglandin synthase inhibitors aysan si wax ku ool ah u joojin karin foosha ilmo-galeenka.
Saamaynta
Atosiban waa antagonist isku dhafan oo ah oxytocin iyo vasopressin V1A, qaab dhismeedkeeda kiimikaad waxay la mid tahay labada, waxayna leedahay xiriir sare oo loogu talagalay reseptors, waxayna la tartameysaa oxytocin iyo vasopressin V1A, taas oo xannibaysa dariiqa ficilka ee oxytocin iyo vasopressin waxayna yareysaa foosha ilmo-galeenka.
