Tianenipine ah nidaamka 5-HT, suuxinta, anti-acetyloline iyo wadnaha ee niyad-jabka

Saamaynta dawooyinka

1. Qaabka ka hortagga lidka ku ah sheygan wuu ka duwan yahay kan TCA dhaqameedka. Waxay ku kordhin kartaa safarka 5-ht ee ku yaal cirifka sayidka, laakiin saameyn daciif ah ayaa ku leh cackke of 5-ht iyo na. Waxay yeelan kartaa saameynta kor u qaadista gudbinta 5-HT neeronal. Maaha wax xiriir ah oo loogu talagalay dhajinta M, H1, α1 iyo α2-Nah.
2. Qiyaasta ka hortagga lidka ku ah sheygan wuxuu la mid yahay kan TCA, oo nabadgelyadeeda iyo dulqaadkiisa ayaa ka wanaagsan TCA (takoorka dawooyinka lidka ku daweeya). Waxtarka badeecadan waxay la mid tahay tan Fogioxetine.
3. Tijaabooyinka daroogada xoolaha ah ayaa muujiyey in ay ku kordhin karto dhaqdhaqaaqa isdaba-joogga ah ee unugyada pyramidal ee ku jira hippocampus iyo dardargelinta soo kabashada shaqadeeda ka dib xannibaadda. Kordhinta dib-u-soo-celinta 5-hydroxyttepmine by neurons ee ceroélex cortex iyo hippocampus.

Cilmi baarista toxicology

- Baadhitaan sunta ah, jahwareerka muddada-dheer iyo muddada-dheer: Wax isbeddelo ah oo ku yimaadda bayoolaji, shaqada beerka, anatomy cudurka.
- Sunta sunta iyo baaritaanka toratogenicity: Tianptne wax saameyn ah kuma lahan awoodda taranka ee waalidiinta la daweeyay iyo uurjiifka iyo farcankiisa.
- Tijaabada Mutagonicicicity: Tianepne ma leh saameyn dhac.

Saamaynta dhinaca

- xanuun entigustric, calool xanuun, afka qalalan, anoexia, lallabbo, matag, calool fadhi, faseelo;
- hurdo la'aan, hurdo la'aan, riyooyinka, daciifnimada;
- tachycardia, xad-dhaafka badan, xanuunka qarsoon;
- Dawakhir, madax xanuun, suuxdin, gariir, wajiga kala baxa;
- neefta oo yaraanta, dareenka ciriiriga ee hunguriga;
- myalgia, xanuunka dhabarka, iwm.