Sildenafil Citrate Daawaynta Kacsiga Kacsiga 171599-83-0
Faahfaahinta Alaabta
| Magaca | Sildenafil Citrate |
| Lambarka CAS | 171599-83-0 |
| qaacidada molecular | C28H38N6O11S |
| Miisaanka molecular | 666.70 |
| Lambarka EINECS | 200-659-6 |
| Merck | 14,8489 |
| Cufnaanta | 1.445g/cm3 |
| Xaaladda kaydinta | 2-8°C |
| Foomka | Budada |
| Midabka | Caddaan |
| Biyuhu milma | DMSO:>20mg/ml |
La mid ah
Viagra, Sildenafil citrate; 1-[[3- (4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1-[[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Qayb-xirfadeed; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl) sulfonyl] phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Saamaynta Dawaynta
Falka dawooyinka
Sildenafil citrate waa 5-phosphodiesterase inhibitor ah oo la xushay kaas oo kor u qaadaya nitric oxide-ku-tiirsanaanta, cyclic guanosine monophosphate-mediated pulmonary vasodilation iyadoo la xakameynayo burburka cyclic guanosine monophosphate. Marka lagu daro ballaarinta tooska ah ee xididdada dhiigga sambabada, waxay sidoo kale ka hortagi kartaa ama dib u habeyn kartaa dib-u-qaabaynta xididdada.
Guryaha Dawooyinka iyo Codsiyada
Sildenafil citrate, magaca ganacsiga Viagre, oo sida caadiga ah loo yaqaan Viagra, waa guanosine monophosphate (cGMP) -oo ah nooca phosphodiesterase nooca 5 (PDE5) kaas oo kor u qaadi kara kacsiga ka dib maamulka afka. Sildenafil citrate waxay kor u qaadi kartaa saameynta nitric oxide (NO) iyada oo la xakameynayo nooca 5 fosfodiesterase kaas oo soo saara cyclic guanosine monophosphate (cGMP) ee cavernosum corpus. Kordhi heerka cGMP ee cavernosum corpus, naso muruqa siman ee cavernosum corpus, kordhiso qulqulka dhiigga, dheeree kacsiga guska oo kordhiso adkaanta. Bukaanka awood la'aanta ah ee qaba cillad kacsi. Dadka waaweyn waxay qaataan 50 mg afka mar kasta, ilaa 1 jeer maalintii, waxayna u isticmaalaan sidii loo baahnaa ilaa 1 saac ka hor galmada. Qadarka ugu badan waa 0.1g mar kasta.
In vivo waxbarashada
Eeyaha la suuxiyay, Sildenafil citrate waxay wanaajisaa shaqada kacsiga guska ee hoos yimaada kicinta dareemayaasha miskaha iyada oo la cabbirayo cadaadiska intracavernous. Sildenafil citrate waxay si muuqata u rogtay nasinta carbamoylcholine ee daciifka ah waxayna joojisay samaynta superoxide ee nudaha cavernosal ee bakaylaha hypercholesterolemic. Jiirka Sprague-Dawley, Sildenafil waxay wanaajisaa shaqada kacsiga ee wakhtiga ku-tiirsanaanta, iyada oo soo kabashada ugu badan ay dhacdo maalinta 28 ee qiyaasta 20 mg / kg maalintii. Jiirka Sprague-Dawley, maamulka Sildenafil waxay keentay ilaalinta saamiga kolajka muruqa oo siman iyo ilaalinta CD31 iyo muujinta eNOS. Jiirka Sprague-Dawley, Sildenafil wuxuu si weyn u yareeyay tusaha apoptotic wuxuuna kordhiyay fosforyaalka akt iyo eNOS marka la barbar dhigo kooxda kantaroolka.
