Preghabalin daaweynta ee loogu talagalay NewerGeral Neuorgo iyo Daaweynta Xaraashka ee suuxdinta qayb ahaan ee deegaan

Saamaynta dawooyinka
Pregbabaal wuxuu leeyahay saameyn ku-daweyn wanaagsan oo ku saabsan suuxdinta. Daraasadaha ku saabsan moodellada suuxdinta xayawaanka ee suuxdinta xayawaanka ayaa muujisay in Pregbabalin ay si weyn uga hortagi karto suuxdinta suuxdinta, oo qaddarka firfircoon ayaa ah 3-10 jeer ka hooseysa heesaha gaboopentin. Daraasaduhu waxay ogaatay in Pregabalin uu yareyn karo dareenka iyo gawaarida laf-dhabarka ee celceliska ee kicinta caqabadaha ee sonkorta, dhaawaca la xiriira dareemayaasha, iyo kiimiko dareemeyaasha, iyo yareynta xanuunka la xiriira xanuunka stinal kicinta laf-dhabarka. akhlaaqda. Daraasadaha xayawaanku waxay ogaadeen in Pregabalin laga yaabo inuu lahaado faa iidooyin isku darka opioids. Preghabalin wuxuu bixiyaa ikhtiyaar cusub oo loogu talagalay daaweynta caafimaad ee xanuunka neuropatathic.

Qaybo mashiin
Pregbabaal wuxuu yareyn karaa sinada u-kasbashada kaalshiyamka ah ee ku-tiirsanaanta qaar ka mid ah neurotrantsmitters-ka iyadoo modugga ka dhex abuuraya kaniishiyamka kaalshiyamka ah. In kasta oo Pregbabaal uu yahay qaab dhismeed qaab-dhismeedka neurotrantter γ-aminobutrinc acid (GABA), gabay), gabab, ama Benzodiazepepers-ka oo aan wax ka badalin Fal-celinta Neaurons-ka ee dhaqan-galiyay, Maskaxda jiirka, oo aan lahayn wax xun oo ku saabsan ka-qaadista Gabake ama nabaad-guurka. Si kastaba ha noqotee, daraasadda ayaa lagu ogaaday in soo-gaadhista daba-galka ah ee neerfayaasha ee loo yaqaan 'pregabilin' ee loo yaqaan 'Pregabilin' oo kordhay cufnaanta gaadiidka ee GABA iyo heerka gaadiidka shaqada ee shaqada. Pregbabaal ma horjoogsanayso kanaalka sodium ah, wax qabad ku ah soo-dhoweynta opioxoseygeniegeninge, oo aan wax dhaqdhaqaaq ah ku lahayn Dopamine iyo soo-celinta 'serotonoin', oo aan horjoogsanayn dib-u-soo-nooleynta dopamine, serotonin, ama norepinephrine. suuragal.

Isdhaxgalka daawada
1. Ma aha wax aan laga qaadin nidaamka 'cytochrome P450, sidaa darteed, si dhif ah ayey ula falgashaa daroogooyinka kale. Ma saameynayso dawooyinka dawooyinka ka hortaga ee ka hortagga ah (sida sodium valproate, partytoin, lamobarbiyen, penobarbiepine, tobazepine-ka, topiramate-ka, wanaagga ka hortaga afka, xariga asliga ah, iyo insulinta.
2. Marka badeecadan loo adeegsado oksigayga, shaqadeeda aqoonsiga ayaa la dhimi doonaa iyo dhaawaca shaqada ee dhaqdhaqaaqa ayaa la xoojin doonaa.
3. Waxay saameyn ku leedahay isku darka lerazepam iyo ethanol.