Waxyaabaha ay ka kooban tahay farmashiyaha
-
Fmoc-Lys(Pal-Glu-OtBu)-OH
Fmoc-Lys(Pal-Glu-OtBu) -OH waa unug dhismeed amino acided gaar ah oo loogu talagalay isku xirka dufanka-peptide. Waxay ka kooban tahay lysine-ka ilaalisa Fmoc oo leh silsilad dhinaca palmitoyl-glutamate, taasoo kor u qaadaysa xidhiidhka xuubka iyo noolaha.
-
Fmoc-His-Aib-OH
Fmoc-His-Aib-OH waa dhisme dipeptide ah oo loo isticmaalo isku-dhafka peptide, isku darka Fmoc-la ilaaliyo histidine iyo Aib (α-aminoisobutyric acid). Aib waxay soo bandhigaysaa qallafsanaan, taasoo ka dhigaysa mid qiimo leh naqshadaynta helical iyo peptides deggan.
-
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH waa jajab tetrapeptide ah oo la ilaaliyo oo loo isticmaalo isku dhafka peptide iyo horumarinta daroogada. Waxay ka kooban tahay kooxo hawleed si istiraatijiyadeed loo ilaaliyo oo loogu talagalay isku dhafka jaranjarada iyo sifooyinka Aib (α-aminoisobutyric acid) si kor loogu qaado xasilloonida helix iyo qallafsanaanta qaabaysan.
-
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU waa unug isku xidhaha dufan leh ee synthetic oo loogu talagalay gaarsiinta daroogada la beegsaday iyo isku-xidhayaasha-daawooyinka-ka-hortagga (ADCs). Waxay ka kooban tahay dabada stearoyl (Ste) hydrophobic, γ-glutamyl ujeedka bartilmaameedka ah, AEEA spacers ee dabacsanaanta, iyo kooxda OSU (NHS ester) ee isku xidhka hufan.
-
Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH waa dhisme la ilaaliyo oo la ilaaliyo oo ka kooban α-methylated leucine, oo caadi ahaan loo isticmaalo naqshadaynta daawada peptide si kor loogu qaado xasilloonida dheef-shiid kiimikaadka iyo xulashada soo-dhoweynta.
-
Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) waa saabuunta zwitterionic synthetic oo si ballaaran loogu isticmaalo cilmi baarista borotiinka xuubabka iyo bayoolaji qaabdhismeedka, gaar ahaan NMR spectroscopy iyo crystallography.
-
Donidalorsen
Donidalorsen API waa oligonucleotide antisense (ASO) oo lagu baarayo daaweynta xanuunka anjioedema ee la iska dhaxlo (HAE) iyo xaaladaha bararka ee la xiriira. Waxaa lagu bartaa macnaha guud ee daaweynta RNA-bartilmaameedka, ujeedadeedu tahay in la yareeyo muujintaplasma prekallikrein(KLKB1 mRNA). Cilmi-baadhayaashu waxay isticmaalaan Donidalorsen si ay u sahamiyaan hababka aamusinta hidda-wadaha, daawooyinka farmashiyaha ku-tiirsan ee qiyaasta, iyo xakamaynta muddada-dheer ee caabuqa dhexdhexaadka ah ee bradykinin.
-
Fitusiran
Fitusiran API waa RNA faragelin yar oo synthetic ah (siRNA) oo ugu horrayn lagu baaro haemophilia iyo xanuunada xinjirowga. Waxay beegsanaysaaantithrombin (AT ama SERPINC1)hidde-sideyaasha beerka si loo yareeyo wax soo saarka antithrombin. Cilmi baadhayaashu waxay u isticmaalaan Fitusiran si ay u sahamiyaan hababka faragelinta RNA (RNAi), aamusinta hidda-socodka beerka-gaarka ah, iyo xeelado daweyn oo cusub oo loogu talagalay dib-u-dheellitirka xinjirowga dhiigga ee bukaannada hemophilia A iyo B, oo leh ama aan lahayn xannibayaal.
-
Givosiran
Givosiran API waa RNA (siRNA) faragelin yar oo synthetic ah oo loo bartay daaweynta cagaarshow ba'an (AHP). Waxay si gaar ah u beegsanaysaaALAS1hiddo-wadaha (aminolevulinic acid synthase 1), kaas oo ku lug leh dariiqa biosynthesis ee heme. Cilmi-baadhayaashu waxay isticmaalaan Givosiran si ay u baaraan faragelinta RNA (RNAi) daaweynta ku salaysan, aamusnaanta hiddo-wadaha beerka, iyo habeynta hababka dheef-shiid kiimikaadka ee ku lug leh porphyria iyo cilladaha hiddaha ee la xiriira.
-
Plozasiran
Plozasiran API waa RNA faragelin yar oo synthetic ah (siRNA) oo loo sameeyay daaweynta hypertriglyceridemia iyo xanuunada wadnaha iyo xididdada dhiigga ee la xiriira. Waxay beegsanaysaaAPOC3hidda-wadaha, kaas oo qeexaya apolipoprotein C-III, oo ah maamulaha muhiimka ah ee dheef-shiid kiimikaadka triglyceride. Cilmi-baarista, Plozasiran waxaa loo isticmaalaa in lagu barto xeeladaha hoos u dhigista dufanka-ku-saleysan ee RNAi, gaarka ah ee aamusnaanta hidda-wadaha, iyo daaweynta muddada-dheer ee daaweynta xaaladaha sida qoyska chylomicronemia syndrome (FCS) iyo dyslipidemia isku dhafan.
-
Zilebesiran
Zilebesiran API waa baaritaan yar oo faragelinaya RNA (siRNA) oo loo sameeyay daawaynta hypertension. Waxay beegsanaysaaAGTHidde-side, kaas oo qeexaya angiotensinogen-waa qayb muhiim ah oo ka mid ah nidaamka renin-angiotensin-aldosterone (RAAS). Cilmi-baarista, Zilebesiran waxaa loo isticmaalaa in lagu barto hababka aamusinta hidda-socodka ee xakamaynta cadaadiska dhiigga ee muddada-dheer, tignoolajiyada gaarsiinta RNAi, iyo doorka ballaaran ee dariiqa RAAS ee cudurrada wadnaha iyo xididdada kelyaha.
-
Caspofungin ee caabuqyada Antifungal
Magaca: Caspofungin
Lambarka CAS: 162808-62-0
Qaaciddada molecular: C52H88N10O15
Miisaanka unugyada: 1093.31
Lambarka EINECS: 1806241-263-5
Barta karkarinta: 1408.1 ± 65.0 °C (La saadaaliyay)
Cufnaanta: 1.36± 0.1 g/cm3 (La saadaaliyay)
Isku-dhafka aysiidhka: (pKa) 9.86±0.26 (La saadaaliyay)