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Leuprerelin acetate wuxuu nidaamiyaa dheecaanka hormoonnada gonadal

Sharraxaadda Gaaban:

Magaca: leuprerelin

Lambarka CAS: 53714-56-0

Qaaciddada molikaulal: c59h84n16o12

Miisaanka Moleculal: 1209.4

Lambarka EINECS: 633-395-9

Wareejin gaar ah: d25 -31.7 ° (c = 1 1% acetic acid)

Cufnaanta: 1.44 ± 0.1 g / cm3 (la saadaaliyay)


Si faahfaafo

Calaamadaha wax soo saarka

Si faahfaafo

Magac Leprelin
Lambarka CAS 53714-56-0
Qaaciddada molika C59h84n16o12
Miisaanka Moleculal 1209.4
Tirada EINECS 633-395-9
Wareejin gaar ah D25 -31.7 ° (c = 1 1% 1% acetic acid)
Cucid 1.44 ± 0.1 g / cm3 (la saadaaliyay)
Xaaladda kaydinta -15 ° C
Qaab Nidaamsan
Isutirka aashitada (PKA) 9.82 ± 0.15 (la saadaaliyay)
Xarkaha biyaha Biyo ku dhex jira 1mg / ml

Ereyo isku mid ah

Lh-rhleuprolide; le'abloside; le'eloide (bini-aadam); Leuprorelin; Leuprelin; -Nhet9) -Letinizingingone-ka-Reaveringingone-(des-gly10, d-leet9, pro-nhe-nhel9) -Let9) -LetinizingringHingone-Cleu6, Pro-Nhe-Nhe-Nheth-RH (Aadanaha)

Saamaynta dawooyinka

Leuproside, Goserelin, Triprelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin, nafarelin waa dhowr daroogo oo caadi ahaan loo isticmaalo dhaqanka kiliinikada si looga saaro ugxanaanta kansarka naasaha ee cudurka kansarka naasaha ee cudurka kansarka dhimirka iyo kansarka qanjirka 'prostate'. (Waxaa loo yaqaan dawooyinka GNRH-daroogo), dawooyinka GNRH-daroogo waxay la mid yihiin qaab-dhismeedka GNRH oo ku tartamaya soo-dhoweynta gnrh gnrh. Taasi waa, gowonadotropin-ka qarsoon ee ay ka kooban tahay hoos udhaca, taas oo horseedaysa hoos u dhac weyn oo ku dhaca hormoonka galmada ee qarsoon ugxanka.

Leuproside waa hormoonka siidaynta-gowlandopin-gnrh) analog, oo ah peptide oo ka kooban 9 amino acids. Alaabtaani waxay si wax ku ool ah u xakameyn kartaa howsha nidaamka pronadal-gonadal, iska caabbinta enzymes enzymyt-ka iyo xidhiidhka ee GNRH-da GNRH ay ka xoog badan yihiin siideynta hormoon-ka-soo-celinta hoormoonka (LH) waa 20 jeer oo GNRH ah. Waxay kaloo leedahay wax laga qaado xannibaadda ka-hortagga ah ee ka shaqeynta ka shaqeynta 'pitutrato-gonad' ka badan GNRH. Marxaladda koowaad ee daaweynta, hormoonka dhiirrigelinta (FSH), LH, estrogen ama androgen-ka ayaa si kumeelgaar ah loo kordhin karaa, oo aan la xakameyn karin, taas oo keentay ku tiirsanaanta hormoonnada galmada. Cudurrada galmada (sida kansarka qanjirka 'prostate', endometriosis, iwm.) Hayso saameyn ku daweynta.

Waqtigan xaadirka ah, cusbada taranka ee lerate ee le'eg ahaan, maxaa yeelay waxqabadka leuproside acetate wuxuu ku xasilloon yahay heerkulka qolka. Dareere waa in la tuuraa. Waxaa loo isticmaali karaa daaweynta daweynta daroogada ee Endometriosis iyo Entroids Fibroids, baaluq udhex-mareenka, kansarka naasaha ee dhismaha iyo kansarka naasaha, iyo sidoo kale dhiigbaxa miyir-beelka ee loo baahan yahay ama aan waxtar lahayn ee loogu talagalay daaweynta hoormoonka caadiga ah. Waxaa sidoo kale loo isticmaali karaa in loo adeegsado waqti ka hor dhimista endometrial, kaas oo si taxaddar leh u dhuujin karo endometrium, yareyn kara bararka, oo yareeyo dhibaatada dhibaatada qalliinka.


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