Leuprorelin Acetate waxay xakameysaa dheecaanka hormoonnada Gonadal
Faahfaahinta Alaabta
| Magaca | Leuprorelin |
| Lambarka CAS | 53714-56-0 |
| qaacidada molecular | C59H84N16O12 |
| Miisaanka molecular | 1209.4 |
| Lambarka EINECS | 633-395-9 |
| Wareegid gaar ah | D25 -31.7° (c = 1 1% acetic acid) |
| Cufnaanta | 1.44±0.1 g/cm3 (La saadaaliyay) |
| Xaaladda kaydinta | -15°C |
| Foomka | nadiif ah |
| Isku-dhafka aysiidhka | (pKa) 9.82±0.15 (La saadaaliyay) |
| Biyuhu milma | Ku milmay biyaha 1mg/ml |
La mid ah
LH-RHLEUPROLIDE, LEUPROLIDE, LEUPROLID (HUMAN); LEUPRORELIN; -NHET9)-LUTEINIZING HORMOONE-SII DAAYA;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-FACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(aadmiga)
Saamaynta Dawaynta
Leuprolide, goserelin, triprelin, iyo nafarelin waa daawooyin dhowr ah oo caadi ahaan loo isticmaalo dhaqanka kiliinikada si meesha looga saaro ugxan-sidaha si loogu daweeyo kansarka naasaha ka hor iyo kansarka qanjirka 'prostate'. (oo loo yaqaan GnRH-daawoyinka), GnRH-daawoyinka waxay la mid yihiin qaab dhismeedka GnRH waxayna la tartamaan daaweeyayaasha GnRH pituitary. Taasi waa, gonadotropin ee ay soo saarto pituitary-ga ayaa hoos u dhacaya, taas oo keenaysa hoos u dhac weyn oo ku yimaada hoormoonka jinsiga ee ay soo saarto ugxan-sidaha.
Leuprolide waa hormoon gonadotropin sii daaya (GnRH), analoog, peptide ka kooban 9 amino acids. Alaabtani waxay si wax ku ool ah u joojin kartaa shaqada nidaamka pituitary-gonadadal, iska caabinta enzymes-ka-proteolytic iyo u-xidhnaanta qanjidhada GnRH ee pituitary ayaa ka xoog badan GnRH, iyo waxqabadka kor u qaadista sii deynta hormoonka luteining (LH) waxay ku saabsan tahay 20 jeer ka GnRH. Waxa kale oo ay leedahay saameyn ka hortag adag oo ku saabsan shaqada pituitary-gonad marka loo eego GnRH. Marxaladda hore ee daaweynta, hoormoonka kicinta follicle (FSH), LH, estrogen ama androgen ayaa laga yaabaa in si ku meel gaar ah loo kordhiyo, ka dibna, sababtoo ah hoos u dhaca jawaab celinta qanjidhada pituitary, dheecaanka FSH, LH iyo estrogen ama androgen waa la joojiyaa, taasoo keentay ku tiirsanaanta hormoonnada jinsiga. Cudurada galmada (sida kansarka qanjirka 'prostate', endometriosis, iwm.) waxay leeyihiin saameyn daweyn.
Waqtigan xaadirka ah, cusbada acetate ee leuprolide waxaa inta badan loo isticmaalaa kiliinikada, sababtoo ah waxqabadka leuprolide acetate waa mid aad u deggan heerkulka qolka. Dareeraha waa in la tuuraa. Waxaa loo isticmaali karaa daaweynta castration daroogada ee endometriosis iyo fibroids uterineine, baaluq dhexe ee precocious, kansarka naasaha premenopausal iyo kansarka qanjirka 'prostate', iyo sidoo kale dhiigbaxa ilmo-galeenka functional kaas oo liddi ku ah ama aan waxtar u lahayn daaweynta hoormoonka caadiga ah. Waxa kale oo loo isticmaali karaa daawo ahaan ka hor inta aan la soo saarin endometrial, kaas oo si siman u khafiifin kara endometrium, hoos u dhigi kara bararka, hoosna u dhigi kara dhibaatada qalliinka.
