Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Codsiga Cilmi-baarista:
Xaruntani waa derivative lysine ah oo wax laga beddelay oo loo isticmaalo isku-dhafka peptide, gaar ahaan dhisidda isku-xidhayaasha peptide-ka ee la bar-tilmaameedsaday ama hawl-galla. Kooxda Fmoc waxay u oggolaaneysaa isku-dubarid si tartiib tartiib ah iyada oo loo marayo Fmoc solid-phase peptide synthesis (SPPS). Silsiladda dhinaca waxa lagu beddelay derivative stearic acid (Ste), γ-glutamic acid (γ-Glu), iyo laba xidhiidhiye AEEA (aminoethoxyethoxyethoxyacetate), kuwaas oo bixiya hydrophobicity, guryaha dallaca, iyo kala dheerayn dabacsan. Caadi ahaan waxaa lagu daraaseeyaa doorka ay ku leedahay hababka gudbinta daroogada, oo ay ku jiraan isku-xidhayaasha-daawoyinka-anti-body-ga (ADCs) iyo peptides-ka unugyada-gala.

Shaqada:
Fmoc-L-Lys[Ste(OtBu))-γ-Glu(OtBu)-AEEA-AEEA] -OH waxay u shaqeysaa sidii dhisme dhisme oo loogu talagalay horumarinta peptides-ka silsiladda dheer ama isku xirayaasha daroogada. Aashitada stearic waxay wanaajisaa xidhiidhka xuubka, γ-Glu waxay wanaajisaa xasilloonida iyo iska caabinta enzymatic, iyo xiriiriyeyaasha AEEA waxay bixiyaan dabacsanaan iyo dabacsanaan qaab dhismeedka. Si wada jir ah, astaamahan ayaa ka dhigaya xarunta mid qiimo leh qaabaynta peptides si loo hagaajiyo bioavailability, siideynta la kantaroolo, iyo codsiyada gaarsiinta la beegsaday.