Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride API
Etelcalcetide Hydrochloride waa calcimimetic peptide synthetic cusub oo loo sameeyay daawaynta hyperparathyroidism secondary (SHPT) ee bukaanada qaba cudurka kelyaha ee raaga (CKD) ee lagu sameeyo hemodialysis. SHPT waa dhibaato caadi ah oo halis ah oo ku dhacda bukaannada CKD, oo lagu garto heerarka hoormoonka parathyroid (PTH), oo khalkhaliyay dheef-shiid kiimikaadka kalsiyum-fosfate, iyo khatarta sii kordheysa ee lafaha iyo cudurada wadnaha.

Etelcalcetide waxay u taagan tahay jiilka labaad ee calcimimetic, oo lagu maamulo xididada, waxayna bixisaa faa'iidooyin daawaynta hore ee afka sida cinacalcet iyadoo hagaajinaysa u hogaansanaanta iyo yaraynta waxyeelada caloosha.

Habka Waxqabadka
Etelcalcetide waxay u shaqeysaa iyada oo ku xireysa oo dhaqaajisa soo-dhoweeyaha kaalshiyam-dareenka (CaSR) ee ku yaal unugyada qanjidhada parathyroid. Tani waxay shabbahaysaa saamaynta jidheed ee kaalshiyamka unugyadu, taasoo horseedaysa:

Xakamaynta dheecaanka PTH

Hoos u dhigista heerka kalsiyumka serum iyo fosfatada

Hagaajinta dheelitirka macdanta iyo dheef-shiid kiimikaadka lafaha

Sida firfircoone-ku-saleysan peptide-ku-saleysan ee CaSR, Etelcalcetide waxay muujineysaa gaar ahaan heer sare ah iyo waxqabad joogto ah ka dib maamulka xididka ka dib sifeynta.

Cilmi-baadhis Caafimaad iyo Saamaynta Daawaynta
Etelcalcetide ayaa si weyn loogu qiimeeyay marxaladda 3 ee tijaabooyinka kiliinikada, oo ay ku jiraan EVOLVE, AMPLIFY, iyo daraasadaha EQUIP. Natiijooyinka muhiimka ah waxaa ka mid ah:

Hoos u dhac weyn oo joogto ah oo ku yimid heerarka PTH ee bukaannada CKD ee hemodialysis

Xakamaynta waxtarka leh ee serum calcium iyo fosfooraska, taas oo gacan ka geysata hagaajinta lafaha-macdanta homeostasis

Dulqaad wanaagsan marka la barbar dhigo calcimimetics afka (lallabbo iyo matag yar)

U hoggaansanaanta bukaanka oo la hagaajiyay sababtoo ah maamulka IV-ga ee saddex jeer toddobaadkii inta lagu jiro kalfadhiyada sifeynta

Faa'iidooyinkan ayaa ka dhigaya Etelcalcetide doorasho daweyn muhiim ah oo loogu talagalay dhakhaatiirta nephrologists ee maamula SHPT ee dadka sifaynta.

Tayada iyo Wax-soo-saarka
Our Etelcalcetide Hydrochloride API:

Waxa lagu farsameeyay iyada oo loo marayo synthesis peptide-fase adag (SPPS) oo leh daahir sare

U hoggaansamaan qeexitaannada heerka-farmasiga, oo ku habboon qaababka la isku duro

Waxay muujisaa heerar hoose ee dareerayaasha haraaga ah, wasakhda, iyo endotoxins

Waa mid loo cabbiri karo wax-soo-saarka dufcadaha waaweyn ee waafaqsan GMP