Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Sharaxaad Gaaban:

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHwaa tetrapeptide la ilaaliyo oo loo isticmaalo isku dhafka peptide iyo daraasaadka qaabdhismeedka. Kooxda Boc (tert-butyloxycarbonyl) waxay ilaalisaa N-terminus, halka kooxaha Trt (tryl) ay ilaaliyaan silsiladaha dhinaca ee histidine iyo glutamine si ay uga hortagaan falcelinta aan loo baahnayn. Joogitaanka Aib (α-aminoisobutyric acid) waxay kor u qaadaysaa is-waafajinta helical waxayna kor u qaadaysaa xasilloonida peptide. peptide-kani waxa uu qiimo u leeyahay baadhista laalaabida peptide-ka, xasiloonida, iyo qaabaynta peptides noolaha firfircoon.

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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Codsiga Cilmi-baarista:
Tetrapeptide-kan la ilaaliyo waxaa loo isticmaalaa isku-dhafka peptide iyo daraasadaha is-waafajinta. Isku darka Aib (α-aminoisobutyric acid) waxay u ogolaataa cilmi-baarayaasha inay baaraan qaababka helicalka iyo habdhaqanka isku laabma ee peptides gaaban. Kooxaha shaqada ee la ilaaliyo (Boc, Trt) waxay xaqiijiyaan xasilloonida iyo xulashada inta lagu jiro isku-darka adag ee peptide-wejiga, taas oo ka dhigaysa qaab qiimo leh oo lagu baranayo dhaqdhaqaaqa laf-dhabarka peptide iyo isdhexgalka silsiladda dhinaca.

Shaqada:
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH waxa ay u adeegtaa qaab dhismeed oo lagu sahamiyo xasiloonida peptide-ka iyo qaabdhismeedka. Aib waxay gacan ka geysataa xasilinta helical, halka histidine iyo haraaga glutamine ay bixiyaan goobo is dhexgalka oo suurtagal ah, faa'iido u leh naqshadeynta peptides bioactive ama ku ekaysiinta jajabyada borotiinka. Waxa kale oo ay horudhac u noqon kartaa peptides-ka shaqaynaya ee horumarinta daroogada ama baadhista biochemical.

Kii hore: Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH

Xiga: Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

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