Zilebesiran

Zilebesiran (API)

Codsiga Cilmi-baarista:
Zilebesiran API waa baaritaan yar oo faragelinaya RNA (siRNA) oo loo sameeyay daawaynta hypertension. Waxay beegsanaysaaAGTHidde-side, kaas oo qeexaya angiotensinogen-waa qayb muhiim ah oo ka mid ah nidaamka renin-angiotensin-aldosterone (RAAS). Cilmi-baarista, Zilebesiran waxaa loo isticmaalaa in lagu barto hababka aamusinta hidda-socodka ee xakamaynta cadaadiska dhiigga ee muddada-dheer, tignoolajiyada gaarsiinta RNAi, iyo doorka ballaaran ee dariiqa RAAS ee cudurrada wadnaha iyo xididdada kelyaha.

Shaqada:
Zilebesiran waxay u shaqeysaa aamusintaAGTmRNA ee beerka, taasoo keentay hoos u dhaca wax soo saarka angiotensinogen. Tani waxay keenaysaa hoos u dhac ku yimaada heerarka angiotensin II, taasoo gacan ka geysaneysa hoos u dhigista cadaadiska dhiigga si joogto ah. API ahaan, Zilebesiran waxay awood u siinaysaa horumarinta daawaynta ka hortagga hypertensive-ka-hooseeya ee muddada-dheer leh ee suurtogalka ah ee qiyaasta rubuc-billaha ah ama sannadlaha ah, iyada oo bixisa u hoggaansanaanta hagaajinta iyo maareynta cadaadiska dhiigga.