Tadialafil 171596-29-5 si loo daweeyo ciribtirka qaladka ee ragga

Tadalafil (Tadalafil, Tadalafil) waxay leedahay qaacido molikal ah oo ah c22h19N3O4 iyo culeys molikal ah oo ah 389.4. Waxaa si weyn loogu isticmaalay daaweynta ragga ectechile ee dhalaasha ah ilaa 2003, oo leh magaca ganacsiga cialis (cialis). Bishii Juun 2009, FDA waxay ansixisay Tadalafil gudaha Mareykanka si loogu daweeyo bukaanka dhiig karka isku-darka sambabka (pah) ee ku hoos jira magaca magaca ADCIMOSA. Tadalafil waxaa lagu soo bandhigay 2003 dawo loogu talagalay daaweynta ed. Waxay dhaqan galeysaa 30 daqiiqo ka dib maamulka, laakiin saamayntiisa ugufiican waa 2h ka dib bilawga ficil, iyo saamayntu waxay socon kartaa 36h, oo saameyntiisu aysan ku dhicin cuntada. Qiyaasta Tagalafil waa 10 ama 20 mg, qiyaasta bilowga ah ee lagu taliyay waa 10 mg, oo qiyaasta waxaa lagu hagaajiyaa iyada oo loo eegayo jawaabta bukaanka iyo falcelinta xun. Daraasadaha suuqa-horay ayaa muujiyay in ka dib maamulka afka ka dib 10 ama 20 mg oo ka mid ah Tadalafil muddo 12 isbuuc ah, heerarka wax ku oolka ah waa 67% iyo 81%, siday u kala horreeyaan. Daraasado badan ayaa muujiyay in Tagalafil ay wax ku ool ah ku leedahay daaweynta ed.

CARECKE CARSFUNFUNK: Tadalafil waa fosfooyin xulasho ah nooca 5 (PDE5) sida Seldenafil, laakiin qaab dhismeedkeedu wuu ka duwan yahay kan dambe, oo cunno dufanku aad u badan ayuu farageliyaa nuugista. Iyada oo la raacayo ficilka kicinta galmada, nitric oxide syntsese (nos) dhamaadka dareemayaasha iyo unugyada xididdada xididdada leh waxay ka hortagaan isku-darka isku-darka nitric oxide (Maya) ee ka soo baxa L-Arrandine. Ma jiro wax u dhaqaajinaya baaskiil wadida Guankylate, kaas oo u beddelaya Guanosine Triphoshosphate-ka quonohosphate (CGMP), taasoo keentay in kacsanaanta murqaha ee isku-darka ah, taasoo keenta kacsanaanta murqaha qunjarka ah ay ku dhacdo nasashada muruqyada jilicsan awgeed. Phosphodiereserase Nooca 5 (PDE5) hoos udhaca CGMP ee alaabada firfircoon, oo guska u dhigaya xaalad daciif ah. Tadalafiil waxay horjoogsanaysaa nabaad-guurka PDE5, taasoo horseedaysa uruurinta CGMP, kaas oo dejinaya murqaha jilicsan ee Corpus Caventosum, oo horseedda kacsiga gubashada. Maaddaama Nitrate-ka aysan ahayn deeq-bixiyeyaal, isku-darka loo adeegsado Tadalafil waxay si weyn u kordhin doontaa heerka CGMP waxayna horseedi doontaa hyptrotect daran. Sidaa darteed, isticmaalka isku-darka labada ayaa lagu xakameynayaa waxqabadka caafimaad.

Tadalafil waxay ka shaqeysaa iyada oo ay ka horjoogsanayso pdes. GMP waa mid liidata, sidaa darteed isku-darka loo adeegsado naitrate-ka ayaa sababi kara hoos u dhac aad u daran oo dhiig karka isla markaana kordhiya halista syncope. Cy3pa4 Intuacires waxay yareyn doontaa bioavafalan ee tamanafiil, iyo isku darka riffaficin, cimetidine, ertromycin, therythroncincin, theryromycin, theretromycin, theretromycin, theretromycin, clarotromycin, clirithromycin, clarotroncin, ka hortagga xargaha xakamaynta dhiigga ayaa laga yaabaa in la hagaajiyo daroogada. Illaa iyo hadda, ma jiraan warbixino sheegaya in xuduudaha dawooyinka dawooyinka dawooyinka dawooyinka ay saameeyaan cuntada iyo aalkolada.