RU-58841 Loo Isticmaalay Sida Ka Hortagga Timaha Darida iyo Bidaarta Qaabka Labka ah
Faahfaahinta Alaabta
| Magaca | RU-58841 |
| Lambarka CAS | 154992-24-2 |
| qaacidada molecular | C17H18F3N3O3 |
| Miisaanka molecular | 369.34 |
| Lambarka EINECS | 1592732-453-0 |
| Barta Karsan | 493.6± 55.0 °C (La saadaaliyay) |
| Cufnaanta | 1.39 |
| Xaaladda kaydinta | Waxaa lagu xidhay qalalan, ku kaydi qaboojiyaha, ka hooseeya -20 ° C |
| Foomka | Budada |
| Midabka | Caddaan |
| Baakad | Bacda PE+Bacda aluminiumka |
La mid ah
RU58841; 4- (4,4-Dimethyl-2,5-dioxo-3- (4-hydroxybutyl) 1-imidazolidinyl) -2- (trifluoromethyl) benzonitrile; onitrile;4-[3- (4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl) ben zonitrile;RU-58841E:candyli(at)speedgainpharma(dot)com;CS-637;RU588841;RU58841;RU58841;RU-58841
Saamaynta Dawaynta
Sharaxaada
RU 58841 (PSK-3841) waa androgen receptor antagonist kaas oo kor u qaada dib u koraan timaha.RU58841 waa daawo baadhiseed oo loo sameeyay daawaynta ka dhanka ah alopecia androgenic, oo sidoo kale loo yaqaano bidaarta raga (MPD).
Sida anti-androgen-ka jirka la mariyo, mabda'a ficilku maaha mid la mid ah kan finasteride. Finasteride wuxuu si toos ah ugu shaqeeyaa 5α reductase, wuxuu joojiyaa beddelka testosterone ee DHT, wuxuuna yareeyaa nuxurka DHT ee jirka. RU58841 waxay xannibaysaa xidhiidhka ka dhexeeya dihydrotestosterone iyo reseptors follicle timaha, si toos ah uma dhimayso nuxurka DHT, laakiin waxay yaraynaysaa xidhitaanka DHT iyo reseptors follicle timaha, si loo gaaro ujeedada daaweynta alopecia androgenetic.
4-[3- (4-Hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2- (trifluoromethyl) benzonitrile waxaa loo isticmaali karaa daawo ahaan Kiimikada isku dhafka ah ee dhexdhexaadinta.Haddii 4-[3- (4-hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2- (trifluoromethyl) benzonitrile la nuugo, U wareeji bukaanka hawo cusub;Haddii ay dhacdo in maqaarka taabto, ka saar dharka wasakhaysan, maqaarka si fiican ugu raaci saabuun iyo biyo, oo raadso daryeel caafimaad haddii raaxo-darro dhacdo;
Saamaynta dhinaca
RU58841 waxa la mariyaa madaxa oo ay nuugtaa timaha follicle-ka, aragti ahaan, waxa ay geli kartaa dhiigga oo saamayn karta qaybaha kale ee jidhka. Laakiin wax saameyn ah oo habaysan lagama helin daraasadaha ku saabsan isticmaalka daanyeerka. Si kastaba ha ahaatee, dadka qaar ee isku dayay RU58841 waxay sheeganayaan inay la kulmeen qaar ka mid ah waxyeelooyinka suurtagalka ah ee isticmaalka RU, oo ay ku jiraan cuncun maqaarka, libido oo yaraaday, cillad kacsi, lallabbo, indho casaan, dawakhaad, iyo madax xanuun.
