Alaabta
-
Givosiran
Givosiran API waa RNA (siRNA) faragelin yar oo synthetic ah oo loo bartay daaweynta cagaarshow ba'an (AHP). Waxay si gaar ah u beegsanaysaaALAS1hiddo-wadaha (aminolevulinic acid synthase 1), kaas oo ku lug leh dariiqa biosynthesis ee heme. Cilmi-baadhayaashu waxay isticmaalaan Givosiran si ay u baaraan faragelinta RNA (RNAi) daaweynta ku salaysan, aamusnaanta hiddo-wadaha beerka, iyo habeynta hababka dheef-shiid kiimikaadka ee ku lug leh porphyria iyo cilladaha hiddaha ee la xiriira.
-
Pegcetacoplan
Pegcetacoplan waa peptide cyclic pegylated kaas oo u shaqeeya sidii horjooge C3 ah oo la beegsanayo, oo loo sameeyay daawaynta cudurrada kaabaya ee dhexdhexaadinta ah sida paroxysmal nocturnal hemoglobinuria (PNH) iyo atrophy juqraafiga (GA) ee hoos u dhaca maskaxda ee da'da.
-
Plozasiran
Plozasiran API waa RNA faragelin yar oo synthetic ah (siRNA) oo loo sameeyay daaweynta hypertriglyceridemia iyo xanuunada wadnaha iyo xididdada dhiigga ee la xiriira. Waxay beegsanaysaaAPOC3hidda-wadaha, kaas oo qeexaya apolipoprotein C-III, oo ah maamulaha muhiimka ah ee dheef-shiid kiimikaadka triglyceride. Cilmi-baarista, Plozasiran waxaa loo isticmaalaa in lagu barto xeeladaha hoos u dhigista dufanka-ku-saleysan ee RNAi, gaarka ah ee aamusnaanta hidda-wadaha, iyo daaweynta muddada-dheer ee daaweynta xaaladaha sida qoyska chylomicronemia syndrome (FCS) iyo dyslipidemia isku dhafan.
-
Zilebesiran
Zilebesiran API waa baaritaan yar oo faragelinaya RNA (siRNA) oo loo sameeyay daawaynta hypertension. Waxay beegsanaysaaAGTHidde-side, kaas oo qeexaya angiotensinogen-waa qayb muhiim ah oo ka mid ah nidaamka renin-angiotensin-aldosterone (RAAS). Cilmi-baarista, Zilebesiran waxaa loo isticmaalaa in lagu barto hababka aamusinta hidda-socodka ee xakamaynta cadaadiska dhiigga ee muddada-dheer, tignoolajiyada gaarsiinta RNAi, iyo doorka ballaaran ee dariiqa RAAS ee cudurrada wadnaha iyo xididdada kelyaha.
-
Palopegteriparatide
Palopegteriparatide waa parathyroid receptor agonist (PTH1R agonist), oo loo sameeyay daawaynta hypoparathyroidism dabadheeraad ah. Waa analooga pegylated ee PTH (1-34) loogu talagalay in lagu bixiyo nidaaminta kaalshiyamka joogtada ah iyadoo la isticmaalayo qiyaas hal mar todobaadkii.
-
GHRP-6
GHRP-6 (Hormoonka Kobaca ee sii daaya Peptide-6) waa hexapeptide synthetic ah oo u dhaqma sida qarsoodiga hoormoonka koritaanka, kicinta sii deynta dabiiciga ah ee jidhka ee hormoonka korriinka (GH) iyadoo la dhaqaajinayo soo-dhoweeyaha GHSR-1a.
Tilmaamaha API:
daahirnimo ≥99%
Lagu soo saaray iyada oo loo marayo isku-dhafka peptide-fase adag (SPPS)
Loo keenay R&D iyo isticmaalka ganacsiga
GHRP-6 waa peptide cilmi baaris badan oo loogu talagalay taageerada dheef-shiid kiimikaadka, dib-u-soo-nooleynta murqaha, iyo habeynta hormoonnada.
-
GHRP-2
GHRP-2 (Hormoonka Kobaca ee sii daaya Peptide-2) waa hexapeptide synthetic iyo secretagogue hoormoonka koritaanka xooggan, loogu talagalay in lagu kiciyo sii deynta dabiiciga ah ee hoormoonka korriinka (GH) iyada oo la dhaqaajinayo soo-dhoweynta GHSR-1a ee hypothalamus iyo pituitary.
Tilmaamaha API:
daahirnimo ≥99%
Loo heli karo R&D iyo sahay ganacsi, oo wata dukumeenti QC oo buuxa
GHRP-2 waa peptide cilmi baaris qiimo leh oo ku saabsan dhinacyada endocrinology, daawada dib u soo kabashada, iyo daawaynta la xiriirta da'da.
-
Hexarelin
Hexarelin waa hormoonka koritaanka synthetic ee secretagogue peptide (GHS) iyo xoog leh GHSR-1a agonist, loo sameeyay si ay u kiciyaan hormoonka koritaanka endogenous (GH) sii daayo. Waxay ka tirsan tahay qoyska ghrelin mimetic waxayna ka kooban tahay lix amino acids (hexapeptide), oo bixisa xasilloonida dheef-shiid kiimikaad iyo saameyn xoog leh oo sii daaya GH marka la barbar dhigo analogs hore sida GHRP-6.
Tilmaamaha API:
daahirnimo ≥ 99%
Waxa lagu soo saaray habka adag ee peptide synthesis (SPPS)
Heerarka u eg GMP, endotoxin hooseeya iyo haraaga dareeraha
Sahayda dabacsan: R&D ilaa miisaanka ganacsiga
-
Melanotan II
Tilmaamaha API:
Nadiifin sare ≥ 99%
Isku-dubbarid iyada oo loo marayo isku-dhafka peptide-wajiga adag (SPPS)
Endotoxin hooseeya, dareerayaasha haraaga ah oo hooseeya
Lagu heli karo R&D ilaa miisaan ganacsi -
Melanotan 1
Melanotan 1 API waxa la soo saaray iyadoo la isticmaalayo tignoolajiyada adag ee peptide synthesis (SPPS) iyada oo la raacayo xaaladaha adag ee tayada GMP-sida.
-
Nadiifin sare ≥99%
-
Waji adag oo peptide synthesis (SPPS)
-
Heerarka wax soo saarka ee GMP
-
Dukumeenti buuxa: COA, MSDS, xogta xasiloonida
-
Sahayda la qiyaasi karo: R&D ilaa heerar ganacsi
-
-
MOTS-C
MOTS-C API waxaa lagu soo saaraa xaalado adag oo GMP u eg iyadoo la adeegsanayo tignoolajiyada adag ee wejiga peptide synthesis (SPPS) si loo hubiyo tayada sare, nadiifnimada sare iyo xasilloonida sare ee cilmi baarista iyo isticmaalka daweynta.
Astaamaha Alaabta:Daahirnimada ≥ 99% (waxaa xaqiijiyay HPLC iyo LC-MS),
endotoxin hooseeya iyo ka kooban dareeraha haraaga ah,
Lagu soo saaray si waafaqsan ICH Q7 iyo borotokool la mid ah GMP,
Wuxuu gaari karaa wax soo saar ballaaran, laga bilaabo heerka milligaraam ee R&D dufcadaha ilaa heerka garaam iyo kiilooga ganacsiga sahayda. -
Ipamorelin
Ipamorelin API waxaa diyaariya heerka sare ** nidaamka isku dhafka peptide wejiga adag (SPPS)** waxaana lagu sameeyaa nadiifin adag iyo tijaabin tayo leh, oo ku habboon isticmaalka dhuumaha hore ee cilmi-baarista sayniska iyo horumarinta iyo shirkadaha dawooyinka.
Tilmaamaha alaabta waxaa ka mid ah:
Daahirnimada ≥99% (tijaabada HPLC)
Ma jiro endotoxin, dareere hadhaa ah oo hooseeya, faddarayn bir ah oo hooseeya
Bixi dukumentiyo tayo leh oo buuxa: COA, warbixinta daraasadda xasilloonida, falanqaynta spectrum nijaasta, iwm.
Heerarka garaam ~ kiiloogaraam la beddeli karo