Alaabta
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU waa unug isku xidhaha dufan leh ee synthetic oo loogu talagalay gaarsiinta daroogada la beegsaday iyo isku-xidhayaasha-daawooyinka-ka-hortagga (ADCs). Waxay ka kooban tahay dabada stearoyl (Ste) hydrophobic, γ-glutamyl ujeedka bartilmaameedka ah, AEEA spacers ee dabacsanaanta, iyo kooxda OSU (NHS ester) ee isku xidhka hufan.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH waa dhisme la ilaaliyo oo la ilaaliyo oo ka kooban α-methylated leucine, oo caadi ahaan loo isticmaalo naqshadaynta daawada peptide si kor loogu qaado xasilloonida dheef-shiid kiimikaadka iyo xulashada soo-dhoweynta.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) waa saabuunta zwitterionic synthetic oo si ballaaran loogu isticmaalo cilmi baarista borotiinka xuubabka iyo bayoolaji qaabdhismeedka, gaar ahaan NMR spectroscopy iyo crystallography.
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N-Acetylneuraminik Acid (Neu5Ac Sialic Acid)
N-Acetylneuraminic Acid (Neu5Ac), oo loo yaqaan sialic acid, waa monosaccharide si dabiici ah u dhaca oo ku lug leh hawlaha unugyada iyo difaaca jirka. Waxay door muhiim ah ka ciyaartaa calaamadaynta unugyada, difaaca pathogene, iyo horumarinta maskaxda.
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Ergothionine
Ergothioneine waa antioxidant dabiici ah oo ka soo jeeda amino acid, oo lagu bartay sifooyinkeeda cytoprotective iyo ka hortagga gabowga. Waxa lagu farsameeyaa fungi iyo bakteeriya waxayna ku ururtaa unugyo soo gaadhay cadaadis oksaydh ah.
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NMN
Daraasadaha hore iyo kuwa hore ee bini'aadamka waxay soo jeedinayaan NMN waxay kor u qaadi kartaa cimri dheer, dulqaadka jireed, iyo waxqabadka garashada.
Tilmaamaha API:
Nadiifin sare ≥99%
Farmashiyo-deer, oo ku habboon qaab-dhismeedka afka ama la isku duro
Lagu soo saaray heerar u eg GMP
NMN API waxay ku habboon tahay isticmaalka kaabayaasha gabowga ka-hortagga, daawaynta dheef-shiid kiimikaadka, iyo cilmi-baarista cimri-dhererka.
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Glucagon
Glucagon waa hoormoon peptide dabiiciga ah oo loo isticmaalo daawaynta degdega ah ee hypoglycemia ba'an waxaana lagu bartay doorka ay ku leedahay nidaaminta dheef-shiid kiimikaadka, dhimista miisaanka, iyo ogaanshaha dheefshiidka.
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Motixafortide
Motixafortide waa peptide synthetic CXCR4 antagonist loo sameeyay si loogu abaabulo unugyada asliga ah ee hematopoietic (HSCs) si loogu tallaalo autologous waxaana sidoo kale lagu bartaa oncology iyo immunotherapy.
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Glepaglutide
Glepaglutide waa analoog GLP-2 oo muddo dheer shaqaynaysa oo loo sameeyay daawaynta xanuunka mindhicirka gaaban (SBS). Waxay xoojisaa nuugista mindhicirka iyo koritaanka, ka caawinta bukaanada inay yareeyaan ku tiirsanaanta nafaqada waalidnimada.
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Elamipretide
Elamipretide waa tetrapeptide-mitochondria-bartilmaameed ah oo loo sameeyay in lagu daweeyo cudurrada ay keento cilladda mitochondrial, oo ay ku jiraan mitochondrial myopathy aasaasiga ah, Barth syndrome, iyo wadnaha oo shaqadiisa gabay.
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Donidalorsen
Donidalorsen API waa oligonucleotide antisense (ASO) oo lagu baarayo daaweynta xanuunka anjioedema ee la iska dhaxlo (HAE) iyo xaaladaha bararka ee la xiriira. Waxaa lagu bartaa macnaha guud ee daaweynta RNA-bartilmaameedka, ujeedadeedu tahay in la yareeyo muujintaplasma prekallikrein(KLKB1 mRNA). Cilmi-baadhayaashu waxay isticmaalaan Donidalorsen si ay u sahamiyaan hababka aamusinta hidda-wadaha, daawooyinka farmashiyaha ku-tiirsan ee qiyaasta, iyo xakamaynta muddada-dheer ee caabuqa dhexdhexaadka ah ee bradykinin.
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Fitusiran
Fitusiran API waa RNA faragelin yar oo synthetic ah (siRNA) oo ugu horrayn lagu baaro haemophilia iyo xanuunada xinjirowga. Waxay beegsanaysaaantithrombin (AT ama SERPINC1)hidde-sideyaasha beerka si loo yareeyo wax soo saarka antithrombin. Cilmi baadhayaashu waxay u isticmaalaan Fitusiran si ay u sahamiyaan hababka faragelinta RNA (RNAi), aamusinta hidda-socodka beerka-gaarka ah, iyo xeelado daweyn oo cusub oo loogu talagalay dib-u-dheellitirka xinjirowga dhiigga ee bukaannada hemophilia A iyo B, oo leh ama aan lahayn xannibayaal.