Alaabta

Nadiifinta Sare ee Peptides Retatrutide 10mg ee Miisaanka dhimista iyo Sonkorowga

daahirnimo:>99%

Gobolka: Budada Lyophilized

Muuqaal: budo cad

Tilmaamaha: 5mg/10mg/15mg/20mg/30mg

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Retatrutide

Retaglutide waa dipeptidyl peptidase-4 (DPP-4) cusub inhibitor fasalka hypoglycemic daroogada taas oo ka hortagi karta hoos u dhaca glucagon-sida peptide-1 (GLP-1) iyo gulukooska-ku-tiirsan insulin-sii daayo polypeptide (GIP) by DPP-4 enzyme ee xiidmaha iyo dhiigga, sii dheeraynaysaa unugyada pancreatic insulin. heerka aasaasiga ah ee insulin soonka, iyada oo la yareynayo dheecaanka glucagon ee unugyada α-pancreatic, si wax ku ool ah loo xakameeyo sonkorta dhiigga ka dib. Waxay si fiican u shaqeysaa marka la eego saameynta hypoglycemic, dulqaadka, iyo u hoggaansanaanta.

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Soodhiyamka Inclisiran

Inclisiran sodium API (Waxyaabaha Farmaceutical Firmaceutical Active) waxaa lagu bartaa ugu horrayn dhanka faragelinta RNA (RNAi) iyo daaweynta wadnaha iyo xididdada dhiigga. Sida siRNA laba-jibbaaran oo lagu beegsanayo hidda-wadaha PCSK9, waxa loo adeegsadaa cilmi-baadhisyo hore iyo kuwo bukaan-socod si loo qiimeeyo xeeladaha aamusinta hidda-wadaha muddada-dheer ee hoos u dhigista LDL-C (kolestaroolka lipoprotein-ka-cufnaanta hoose). Waxa kale oo ay u adeegtaa sidii qaab dhismeed oo loogu talagalay baadhista hababka gudbinta siRNA, xasilloonida, iyo daaweynta RNA ee beerka-la beegsado.

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Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH waa dipeptide loo isticmaalo sidii dhisme aasaasi ah oo ku jira isku-dhafka peptide-wejiga adag (SPPS). Waxay ka kooban tahay laba hadhaaga glycine iyo N-terminus-ilaaliya Fmoc, taas oo u oggolaanaysa dhererka silsiladda peptide ee kontoroolka ah. Sababtoo ah cabbirka yar ee glycine iyo dabacsanaanta, dipeptide-kan waxaa badanaa lagu bartaa macnaha guud ee dhaqdhaqaaqa laf-dhabarka peptide, naqshadeynta isku xirka, iyo qaabeynta qaabdhismeedka peptides iyo borotiinnada.

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Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr (tBu) -Phe-OH waa dhisme dipeptide ah oo caadi ahaan loo isticmaalo isku-dhafka peptide-wajiga adag (SPPS). Kooxda Fmoc (9-fluorenylmethyloxycarbonyl) waxay ilaalisaa N-terminus, halka kooxda tBu (tert-butyl) ay ilaaliso silsiladda dhinaca hydroxyl ee threonine. Dipeptide-kan la ilaaliyo waxaa lagu daraaseeyaa doorka ay ku leedahay fududaynta fidinta peptide-ka hufan, yaraynta jinsiyada, iyo qaabaynta mawduucyo taxane ah oo gaar ah oo ku saabsan qaabka borotiinka iyo daraasadaha isdhexgalka.

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AEEA-AAEEA

AEEA-AEEA waa hydrophilic, spacer dabacsan oo caadi ahaan loo isticmaalo peptide iyo cilmi-baarista isku xirka daroogada. Waxay ka kooban tahay laba qaybood oo ah ethylene glycol, taas oo ka dhigaysa mid faa'iido u leh barashada saameynta dhererka iskuxiraha iyo dabacsanaanta isdhexgalka molecular, solubility, iyo dhaqdhaqaaqa noolaha. Cilmi-baadhayaashu waxay inta badan isticmaalaan cutubyada AEEA si ay u qiimeeyaan sida spacers u saameeyaan waxqabadka isku-xidhayaasha daawada-antibody-ga (ADCs), conjugates-peptide-daroogada, iyo bioconjugates kale.

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Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Xaruntani waa derivative lysine ah oo la ilaaliyo, shaqaynaysa oo loo isticmaalo isku-dhafka peptide iyo horumarinta isku-xidhka daroogada. Waxay ka kooban tahay kooxda Fmoc ee ilaalinta N-terminal, iyo wax ka beddelka silsiladda dhinaca Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), iyo AEEA (aminoethoxyethoxyacetate). Qaybahan waxaa loogu talagalay in lagu barto saamaynta lipidation-ka, kimistariga spacer-ka, iyo siidaynta daawada la xakameeyey. Waxaa si weyn loo baaraa iyadoo la eegayo istaraatiijiyadaha dawooyinka soo saara, isku xirayaasha ADC, iyo peptides-ka dhex gala xuubabka.

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Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Xaruntani waa derivative lysine ah oo wax laga beddelay oo loo isticmaalo isku-dhafka peptide, gaar ahaan dhisidda isku-xidhayaasha peptide-ka ee la bar-tilmaameedsaday ama hawl-galla. Kooxda Fmoc waxay u oggolaaneysaa isku-dubarid si tartiib tartiib ah iyada oo loo marayo Fmoc solid-phase peptide synthesis (SPPS). Silsiladda dhinaca waxa lagu beddelay derivative stearic acid (Ste), γ-glutamic acid (γ-Glu), iyo laba xidhiidhiye AEEA (aminoethoxyethoxyethoxyacetate), kuwaas oo bixiya hydrophobicity, guryaha dallaca, iyo kala dheerayn dabacsan. Caadi ahaan waxaa lagu daraaseeyaa doorka ay ku leedahay hababka gudbinta daroogada, oo ay ku jiraan isku-xidhayaasha-daawoyinka-anti-body-ga (ADCs) iyo peptides-ka unugyada-gala.

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Liraglutide Anti-Diabetics ee Xakamaynta Sonkorta Dhiiga CAS NO.204656-20-2

Walaxda firfircoon:Liraglutide (analog of glucagon-like peptide-1 (GLP-1) oo ay soo saartay khamiir iyada oo loo marayo tignoolajiyada dib-u-habaynta hidda-socodka).

Magaca Kiimikada:Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]

Waxyaabaha kale:Disodium Hydrogen Fosfate Dihydrate, Propylene Glycol, Hydrochloric Acid iyo/ama Sodium Hydroxide (sida hagaajinta pH Keliya), Phenol, iyo Biyaha la isku duro.

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Leuprorelin Acetate waxay xakameysaa dheecaanka hormoonnada Gonadal

Magaca: Leuprorelin

Lambarka CAS: 53714-56-0

Qaaciddada molecular: C59H84N16O12

Miisaanka molecular: 1209.4

Lambarka EINECS: 633-395-9

Wareeg gaar ah: D25 -31.7° (c = 1 1% acetic acid)

Cufnaanta: 1.44± 0.1 g/cm3 (La saadaaliyay)

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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHwaa tetrapeptide la ilaaliyo oo loo isticmaalo isku dhafka peptide iyo daraasaadka qaabdhismeedka. Kooxda Boc (tert-butyloxycarbonyl) waxay ilaalisaa N-terminus, halka kooxaha Trt (tryl) ay ilaaliyaan silsiladaha dhinaca ee histidine iyo glutamine si ay uga hortagaan falcelinta aan loo baahnayn. Joogitaanka Aib (α-aminoisobutyric acid) waxay kor u qaadaysaa is-waafajinta helical waxayna kor u qaadaysaa xasilloonida peptide. peptide-kani waxa uu qiimo u leeyahay baadhista laalaabida peptide-ka, xasiloonida, iyo qaabaynta peptides noolaha firfircoon.

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BPC-157

BPC-157 API waxay qabataa habka isku-dhafka wajiga adag (SPPS):
Nadiifin sare: ≥99% (HPLC ogaanshaha)
Hadhaaga wasakhda hoose, ma laha endotoxin, ma laha wasakhowga birta culus
Xasilooni Dufcaddii, ku celin xoog leh, isticmaalka heerka duritaanka taageerada
Taageero sahayda garaam iyo kiiloogaraam si loo daboolo baahiyaha heerarka kala duwan ee R&D ilaa warshadaynta.

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