Soodhiyamka Inclisiran

Inclisiran Sodium (API)

Codsiga Cilmi-baarista:
Inclisiran sodium API (Waxyaabaha Farmaceutical Firmaceutical Active) waxaa lagu bartaa ugu horrayn dhanka faragelinta RNA (RNAi) iyo daaweynta wadnaha iyo xididdada dhiigga. Sida siRNA laba-jibbaaran oo lagu beegsanayo hidda-wadaha PCSK9, waxa loo adeegsadaa cilmi-baadhisyo hore iyo kuwo bukaan-socod si loo qiimeeyo xeeladaha aamusinta hidda-wadaha muddada-dheer ee hoos u dhigista LDL-C (kolestaroolka lipoprotein-ka-cufnaanta hoose). Waxa kale oo ay u adeegtaa sidii qaab dhismeed oo loogu talagalay baadhista hababka gudbinta siRNA, xasilloonida, iyo daaweynta RNA ee beerka-la beegsado.

Shaqada:
Inclisiran sodium API waxay u shaqeysaa iyada oo aamusinaysa hidda-wadaha PCSK9 ee hepatocytes, taasoo horseedaysa hoos u dhaca soosaarka borotiinka PCSK9. Tani waxay keenaysaa dib-u-warshadaynta kor loo qaaday ee LDL reseptors iyo nadiifinta weyn ee kolestaroolka LDL ee dhiiga. Shaqadeeda sida wakiilka hoos u dhiga kolestaroolka oo muddo dheer shaqaynayey waxay taageertaa isticmaalkeeda daaweynta hypercholesterolemia iyo yaraynta khatarta cudurrada wadnaha iyo xididdada dhiigga. API ahaan, waxay ka samaysaa qaybta firfircoonida ee udub dhexaadka u ah hababka daroogada ee ku salaysan Inclisiran.