Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Codsiga Cilmi-baarista:
Fmoc-Thr (tBu) -Phe-OH waa dhisme dipeptide ah oo caadi ahaan loo isticmaalo isku-dhafka peptide-wajiga adag (SPPS). Kooxda Fmoc (9-fluorenylmethyloxycarbonyl) waxay ilaalisaa N-terminus, halka kooxda tBu (tert-butyl) ay ilaaliso silsiladda dhinaca hydroxyl ee threonine. Dipeptide-kan la ilaaliyo waxaa lagu daraaseeyaa doorka ay ku leedahay fududaynta fidinta peptide-ka hufan, yaraynta jinsiyada, iyo qaabaynta mawduucyo taxane ah oo gaar ah oo ku saabsan qaabka borotiinka iyo daraasadaha isdhexgalka.

Shaqada:
Fmoc-Thr (tBu) -Phe-OH waxay u adeegtaa sidii horudhac loogu talagalay isku-darka peptides oo ay ku jiraan haraaga threonine iyo phenylalanine, kuwaas oo muhiim u ah sameynta curaarta hydrogen iyo isdhexgalka hydrophobic. Silsiladda threonine waxay gacan ka geysataa polarity iyo goobaha fosforyaalka ee suurtogalka ah, halka phenylalanine ay ku darayso dabeecad udgoon iyo xasilloonida qaabdhismeedka. Isku dhafkan ayaa faa'iido u leh naqshadeynta peptides ee qiimeynta bayoolojiga, daraasaadka xiritaanka soo-dhoweynta, iyo codsiyada helitaanka daroogada.