Fitusiran

Fitusiran (API)

Codsiga Cilmi-baarista:
Fitusiran API waa RNA faragelin yar oo synthetic ah (siRNA) oo ugu horrayn lagu baaro haemophilia iyo xanuunada xinjirowga. Waxay beegsanaysaaantithrombin (AT ama SERPINC1)hidde-sideyaasha beerka si loo yareeyo wax soo saarka antithrombin. Cilmi baadhayaashu waxay u isticmaalaan Fitusiran si ay u sahamiyaan hababka faragelinta RNA (RNAi), aamusinta hidda-socodka beerka-gaarka ah, iyo xeelado daweyn oo cusub oo loogu talagalay dib-u-dheellitirka xinjirowga dhiigga ee bukaannada hemophilia A iyo B, oo leh ama aan lahayn xannibayaal.

Shaqada:
Fitusiran waxay u shaqeysaa iyadoo aamusisa muujinta antithrombin, xinjirowga lidka ku ah dabiiciga ah, taas oo kordhinaysa jiilka thrombin iyo kor u qaadida samaynta xinjirowga. Habkani wuxuu bixiyaa hab daawayn ka hortag ah si loo yareeyo dhacdooyinka dhiigbaxa ee bukaanka hemophilia. API ahaan, Fitusiran waxay u adeegtaa sida walaxda firfircoon ee daawaynta jirka hoosteeda ee shaqaynaysa muddada dheer ee loogu talagalay in lagu wanaajiyo tayada nolosha iyo dhimista culayska daaweynta cudurrada dhiigbaxa.