NAD + waa koenzyme lagama maarmaanka u ah hababka nolosha gacanta, ka ciyaara doorka dhexe ee dheef-shiid kiimikaadka tamarta, hagaajinta DNA-da iyo gabowga, jawaab-celinta cadaadiska gacanta iyo xakamaynta calaamadaha, iyo sidoo kale ilaalinta neuroprotection. Dheef-shiid kiimikaad tamarta, NAD + waxay u shaqeysaa sidii gudbiyaha elektaroonigga ah ee muhiimka ah ee glycolysis, wareegga tricarboxylic acid, iyo fosforyaalka oxidative ee mitochondrial, wadista isku dhafka ATP iyo bixinta tamarta howlaha gacanta. Isla mar ahaantaana, NAD + waxay u adeegtaa sidii qayb muhiim ah oo loogu talagalay enzymes dayactirka DNA iyo firfircoonida sirtuins, taas oo ilaalinaysa xasilloonida genomic waxayna gacan ka geysaneysaa cimriga dheer. Marka la eego xaaladaha cadaadiska oksaydhka iyo bararka, NAD + waxay ka qaybqaadataa waddooyinka calaamadaynta iyo xakamaynta calcium si loo ilaaliyo homeostasis-ka gacanta. Nidaamka dareenka, NAD + waxay taageertaa shaqada mitochondrial, waxay yaraynaysaa dhaawaca oksaydhka, waxayna caawisaa dib u dhigista bilawga iyo horumarka cudurada neurodegenerative. Maadaama heerarka NAD + ay si dabiici ah hoos ugu dhacayaan da'da, xeeladaha lagu ilaalinayo ama lagu wanaajinayo NAD + ayaa si isa soo taraysa loogu aqoonsanayaa inay muhiim u tahay horumarinta caafimaadka iyo gaabinta gabowga.